What is the half-life of a recombinant or natural protein in culture at 37 °C?

R&D Systems has not determined the half-life of recombinant or natural proteins in culture. For cell-based bioassays, the incubation period of the protein with the cells typically ranges from 48 to 96 hours. Assay conditions for each protein will need to be optimized by each researcher.

Can Recombinant Human BMP-4 Protein (Catalog # 314-BP or 314-BP/CF) be reconstituted in PBS or water?

Recombinant Human BMP-4 (Catalog # 314-BP or 314-BP/CF) needs to be reconstituted to 50-200 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl to ensure optimal recovery, stability, and activity. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

Recombinant Human BMP-4 Protein

Name: Recombinant Human BMP-4 Protein
Brand: rnd
SKU: 314-BP
Rating: 5 (8 reviews)

Catalog # 314-BP

Citations (368)

(8)

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Key Product Details

Source:	NS0
Accession #:	Q53XC5
Structure / Form:	Disulfide-linked homodimer
Applications:	Bioactivity

View Full Technical Details for Recombinant Human BMP-4 Protein

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Product Specifications

Source	Mouse myeloma cell line, NS0-derived human BMP-4 protein Ser293-Arg408
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin level	<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Ser293
Predicted Molecular Mass	13 kDa (monomer)
SDS-PAGE	22-25 kDa, reducing conditions 37-41 kDa, non-reducing conditions
Activity	Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED₅₀ for this effect is typically 2.5-15 ng/mL.

Recombinant Human BMP-4 Protein Scientific Data Examples

	Recombinant Human BMP-4 Protein Bioactivity Recombinant Human BMP-4 (Catalog # 314-BP/CF) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀for this effect is 2.5-15 ng/mL.
	Recombinant Human BMP-4 Protein SDS-PAGE 1 ug/lane of Recombinant Human BMP-4 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 22-25 kDa and 37-41 kDa, respectively. Multiple bands in gel are due to variable glycosylation.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

314-BP

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution	Reconstitute at 50-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution.

314-BP/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution	Reconstitute at 50-200 μg/mL in sterile 4 mM HCl.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BMP-4

BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5). The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). Processing of the propeptide by furin or proprotein convertase 6 enables the formation of the mature disulfide-linked homodimeric BMP-4 and facilitates its secretion. Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7
disulfide-linked heterodimer (7-9). Mature human and mouse BMP-4 share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identity with human BMP-2 and less than 50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15).

Item	Value
References	Zhang, P. et al. (2008) Blood 111:1933. Gambaro, K. et al. (2006) Cell Death Differ. 13:1075. Simic, P. and S. Vukicevic (2005) Cytokine Growth Factor Rev. 16:299. Sadlon, T.J. et al. (2004) Stem Cells 22:457. Frank, D.B. et al. (2005) Circ. Res. 97:496. Wozney, J. et al. (1988) Science 242:1528. Cui, Y. et al. (1998) EMBO J. 17:4735. Cui, Y. et al. (2001) Genes Dev. 15:2797. Aono, A. et al. (1995) Biochem. Biophys. Res. Commun. 210:670. Nishimatsu, S. and G.H. Thomsen (1998) Mech. Dev. 74:75. Chen, D. et al. (2004) Growth Factors 22:233. Lavery, K. et al. (2008) J. Biol. Chem. April 24 epub. Rosen, V. (2006) Ann. N.Y. Acad. Sci. 1068:19. Jones, C.M. and J.C. Smith (1998) Dev. Biol. 194:12. Takada, T. et al. (2003) J. Biol. Chem. 278:43229.
Long Name	Bone Morphogenetic Protein 4
Entrez Gene IDs	652 (Human); 12159 (Mouse); 25296 (Rat); 30612 (Zebrafish)
Alternate Names	BMP-2B, BMP-4, BMP2B, BMP2B1, BMP2BMCOPS6, BMP4, Bone morphogenetic protein 2B, DVR4, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4

Citations (368)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human BMP-4 Protein include:

Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

T Pan et al. (2020), Cabozantinib Reverses Renal Cell Carcinoma-Mediated Osteoblast Inhibition in Three-Dimensional Co-culture In Vitro and Reduces Bone Osteolysis In Vivo Mol. Cancer Ther., 0(0):.
PMID: 32220969
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

T Kroon et al. (2020), PPAR&gamma and PPAR&alpha synergize to induce robust browning of white fat inï¿½vivo Mol Metab, 36(0):100964.
PMID: 32248079
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

H Liang et al. (2020), TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes Stem Cell Res Ther, 11(1):196.
PMID: 32448362
Species: Mouse

Applications: Bioassay

K Takahashi et al. (2020), Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells Cell Rep, 31(9):107715.
PMID: 32492424
Species: Human

Applications: Bioassay

M Nafria et al. (2020), Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells Cell Rep, 31(8):107691.
PMID: 32460028
Species: Human
Sample Types: cell culture

K Takeishi et al. (2020), Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells Cell Rep, 31(9):107711.
PMID: 32492423
Species: Human

Applications: Bioassay

M Martin-Fer et al. (2020), Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions Cell Rep, 31(6):107633.
PMID: 32402279
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Matsumoto et al. (2020), Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells J. Clin. Invest., 130(2):641-654.
PMID: 31845906
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Giacomelli et al. (2020), Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease Cell Stem Cell, 26(6):862-879.e11.
PMID: 32459996
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

A Krouwels et al. (2020), Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration Int J Mol Sci, 21(8):.
PMID: 32295299
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

M Grosch et al. (2020), Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation BMC Biol., 18(1):42.
PMID: 32321486
Species: Human

Applications: Cell Culture

J Wesely et al. (2020), Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 31(9):107688.
PMID: 32492433
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Yan et al. (2020), Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming Cell Rep, 32(1):107870.
PMID: 32640235
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Yamashiro et al. (2020), Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 15(4):1560-1583.
PMID: 32231324
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AS Ibrahim et al. (2020), Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration J Clin Med, 9(7):.
PMID: 32707711
Species: Human
Sample Types: cell culture
Applications: Cell Culture

NJ Hogrebe et al. (2020), Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 0(0):.
PMID: 32094658
Species: Human
Sample Types: Cells
Applications: Cell Culture

Y Wang et al. (2020), HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 21(3):274-286.
PMID: 32066947
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Montel-Hag et al. (2019), Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells Cell Stem Cell, 0(0):.
PMID: 30661959
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

C Song et al. (2019), Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Stem Cell Reports, 0(0):.
PMID: 31353224
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Nasri et al. (2019), CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 0(0):.
PMID: 31248972
Species: Human
Sample Types: Organoid
Applications: Bioassay

JM Segal et al. (2019), Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors Nat Commun, 10(1):3350.
PMID: 31350390
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Yoshimatsu et al. (2019), A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology PLoS ONE, 14(8):e0221164.
PMID: 31454364
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Q Mei et al. (2019), Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation Nat Commun, 10(1):4416.
PMID: 31562321
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Inoue et al. (2019), Autonomous trisomic rescue of Down syndrome cells Lab. Invest., 0(0):.
PMID: 30760866
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Yan et al. (2019), Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells Sci Rep, 9(1):1295.
PMID: 30718597
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Ito et al. (2019), Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep, 9(1):1881.
PMID: 30760836
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zheng et al. (2019), Controlled modelling of human epiblast and amnion development using stem cells Nature, 573(7774):421-425.
PMID: 31511693
Species: Human
Sample Types: Whole Cells
Applications: Tissue Culture

R Sachdeva et al. (2019), BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma Sci Rep, 9(1):14569.
PMID: 31602000
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Liang et al. (2019), Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 0(0):.
PMID: 31648393
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

W Song et al. (2019), Engineering transferrable microvascular meshes for subcutaneous islet transplantation Nat Commun, 10(1):4602.
PMID: 31601796
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

S Fujisawa et al. (2019), Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells Peptides, 0(0):.
PMID: 30721716
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HJ Bai et al. (2019), SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells through Mediating the Transcriptional Activation of Key Mesendodermal Genes Stem Cells, 0(0):.
PMID: 31348575
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Barber et al. (2019), Derivation of enteric neuron lineages from human pluripotent stem cells Nat Protoc, 14(4):1261-1279.
PMID: 30911172
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Pecha et al. (2019), Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model Sci Rep, 9(1):9831.
PMID: 31285568
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TR Broda et al. (2019), Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 14(1):28-50.
PMID: 30470820
Species: Chicken
Sample Types: Tissue Explants
Applications: Bioassay

WKW Ho et al. (2019), Feather arrays are patterned by interacting signalling and cell density waves PLoS Biol., 17(2):e3000132.
PMID: 30789897
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Xu et al. (2019), Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 0(0):.
PMID: 30853558
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Okada et al. (2019), Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia Sci Rep, 9(1):4695.
PMID: 30886174
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Yan et al. (2019), FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration Cell Stem Cell, 0(0):.
PMID: 30661960
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Toba et al. (2019), FGF signal is not required for hepatoblast differentiation of human iPS cells Sci Rep, 9(1):3713.
PMID: 30842525
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Grajcarek et al. (2019), Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 10(1):4856.
PMID: 31649251
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Hoshino et al. (2019), Synchrony and asynchrony between an epigenetic clock and developmental timing Sci Rep, 9(1):3770.
PMID: 30842553
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AM Blázquez-M et al. (2019), Noggin depletion in adipocytes promotes obesity in mice Mol Metab, 0(0):.
PMID: 31027994
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AD Senft et al. (2019), Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse Nat Commun, 10(1):1089.
PMID: 30842446
Species: Human
Sample Types: Tissue Explants
Applications: Bioassay

MJ Harms et al. (2019), Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes Cell Rep, 27(1):213-225.e5.
PMID: 30943403
Species: Human
Sample Types: cell culture
Applications: Differentiation

B Mair et al. (2019), Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 27(2):599-615.e12.
PMID: 30970261
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Colunga et al. (2019), Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 26(10):2566-2579.e10.
PMID: 30840882
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Li et al. (2019), TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment Cell Stem Cell, 0(0):.
PMID: 30686763
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Veschi et al. (2019), Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 0(0):.
PMID: 31591478
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Kuwahara et al. (2019), Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue Sci Rep, 9(1):18936.
PMID: 31831759
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Stubb et al. (2019), Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells Nat Commun, 10(1):4756.
PMID: 31628312
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Sahabian et al. (2019), Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential Cells, 8(12):.
PMID: 31817235
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

STJ Bradford et al. (2019), High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds J. Biol. Chem., 0(0):.
PMID: 30602563
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Jacob et al. (2019), Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells Nat Protoc, 0(0):.
PMID: 31732721
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

D Seo et al. (2019), The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine, 49(0):55-71.
PMID: 31685442
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

GL Tiemeier et al. (2019), Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation Stem Cell Reports, 13(5):803-816.
PMID: 31680061
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Z Li et al. (2019), Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells Stem Cell Res Ther, 10(1):324.
PMID: 31730021
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

D Chen et al. (2019), Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors Cell Rep, 29(13):4568-4582.e5.
PMID: 31875561
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RMJ Genga et al. (2019), Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development Cell Rep, 27(3):708-718.e10.
PMID: 30995470
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Roudnicky et al. (2019), Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype Int J Mol Sci, 20(24):.
PMID: 31835296
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Sattler et al. (2019), Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes Sci Rep, 9(1):5651.
PMID: 30948775
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nagel et al. (2019), NKL homeobox gene activities in normal and malignant myeloid cells PLoS ONE, 14(12):e0226212.
PMID: 31825998
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Matsuura et al. (2019), Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates Regen Ther, 12(0):6-13.
PMID: 31890761
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ali et al. (2019), Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 9(1):18552.
PMID: 31811247
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AD Senft et al. (2018), Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming Cell Rep, 24(8):1977-1985.e7.
PMID: 30134160
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Yoney et al. (2018), WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Elife, 7(0):.
PMID: 30311909
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Pursani et al. (2018), Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage Stem Cell Res Ther, 9(1):97.
PMID: 29631608
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2018), Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 0(0):9636897187803.
PMID: 29895168
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Buskin et al. (2018), Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa Nat Commun, 9(1):4234.
PMID: 30315276
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Devito et al. (2018), Induced pluripotent stem cell line from an atopic dermatitis patient heterozygous for c.2282del4 mutation in filaggrin: KCLi001-A Stem Cell Res, 31(0):122-126.
PMID: 30075366
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Kirino et al. (2018), Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition Sci Rep, 8(1):12865.
PMID: 30150715
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Magro-Lope et al. (2018), Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 9(1):186.
PMID: 29996941
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Z Xu et al. (2018), Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes Stem Cell Res Ther, 9(1):211.
PMID: 30092828
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JJ Gell et al. (2018), PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation Stem Cell Res, 27(0):46-56.
PMID: 29324254
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Di Baldass et al. (2018), Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids Sci Rep, 8(1):12028.
PMID: 30104705
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Delsing et al. (2018), Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier Stem Cells, 0(0):.
PMID: 30171748
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Koefoed et al. (2018), The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 8(1):9542.
PMID: 29934521
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2018), 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 0(0):.
PMID: 30244870
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Chen et al. (2018), The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation Cell Rep, 25(13):3591-3602.e5.
PMID: 30590035
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Tengroth et al. (2018), Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps Sci Rep, 8(1):1561.
PMID: 29367682
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Frank et al. (2018), yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs Cell Stem Cell, 0(0):.
PMID: 30554961
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SS Adkar et al. (2018), Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing Stem Cells, 0(0):.
PMID: 30378731
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CC Weng et al. (2018), Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis Oncogene, 0(0):.
PMID: 30467381
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JM Pattison et al. (2018), Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment Nat. Genet., 0(0):.
PMID: 30397335
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JGW Smith et al. (2018), Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits Stem Cell Reports, 0(0):.
PMID: 30392975
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Y Kang et al. (2018), Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys Cell Rep, 25(9):2563-2576.e9.
PMID: 30485820
Species: Chicken
Sample Types: Embryo
Applications: Bioassay

P Ray et al. (2018), Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping Proc. Natl. Acad. Sci. U.S.A., 0(0):.
PMID: 30459275
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Guo et al. (2018), A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 0(0):.
PMID: 29754779
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YC Chen et al. (2018), ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA Cell Death Dis, 9(4):437.
PMID: 29740017
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RA Sierra et al. (2018), TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency Development, 0(0):.
PMID: 29361574
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Okamoto et al. (2018), Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B Cell Transplant, 27(2):299-309.
PMID: 29637813
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JS Esser et al. (2018), Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells FEBS J., 0(0):.
PMID: 29473997
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Jun et al. (2018), An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling Nat. Med., 0(0):.
PMID: 29785025
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Jin et al. (2018), Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery PLoS ONE, 13(3):e0194895.
PMID: 29579079
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Yachie-Kin et al. (2018), Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions Mol. Syst. Biol., 14(1):e7952.
PMID: 29378814
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EJ Ostrin et al. (2018), Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 0(0):.
PMID: 29440304
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Kondrashov et al. (2018), Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells Stem Cells Dev., 0(0):.
PMID: 29402189
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Wang et al. (2018), Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype Int J Mol Sci, 19(2):.
PMID: 29419805
Species: Human
Sample Types: Whole Cells
Applications: Differentiation

T Yamashita et al. (2018), Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells Biochem. Biophys. Res. Commun., 0(0):.
PMID: 29409945
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Long et al. (2018), Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing Sci Adv, 4(1):eaap9004.
PMID: 29404407
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Yücel et al. (2017), Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes Sci Rep, 7(1):2935.
PMID: 28592841
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Harding et al. (2017), Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways Stem Cells, 0(0):.
PMID: 28248004
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

P Scerbo et al. (2017), Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2 Elife, 6(0):.
PMID: 28654420
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Raja et al. (2017), Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells Oncogene, 0(0):.
PMID: 28459464
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Koike et al. (2017), Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism Development, 0(0):.
PMID: 28219950
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2017), Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells Nat Protoc, 12(1):15-31.
PMID: 27906170
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MT Uemura et al. (2017), Pericyte-derived Bone Morphogenetic Protein 4 Underlies White Matter Damage after Chronic Hypoperfusion Brain Pathol., 0(0):.
PMID: 28470822
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NG Kooreman et al. (2017), Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics Cell Rep, 20(8):1978-1990.
PMID: 28834758
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Kajiwara et al. (2017), Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Stem Cell Reports, 8(6):1701-1713.
PMID: 28591652
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DW Hammers et al. (2017), Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 0(0):.
PMID: 28270449
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

C Sallon et al. (2017), Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 0(0):.
PMID: 28747434
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Giacomelli et al. (2017), Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells Development, 144(6):1008-1017.
PMID: 28279973
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Sakurai et al. (2017), Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Sci Rep, 7(0):45698.
PMID: 28374759
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

BA Boswell et al. (2017), Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract Mol. Biol. Cell, 0(0):.
PMID: 28209733
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BW Ellis et al. (2017), Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine Biomicrofluidics, 11(2):024105.
PMID: 28396709
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Mitani et al. (2017), Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Mol. Ther., 25(6):1420-1433.
PMID: 28462819
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

K Ogura-Ochi et al. (2017), Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells Peptides, 0(0):.
PMID: 28627372
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JW Park et al. (2017), Recapitulating and Correcting Marfan Syndrome in a Cellular Model Int. J. Biol. Sci., 13(5):588-603.
PMID: 28539832
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Hawkins et al. (2017), Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells J. Clin. Invest., 127(6):2277-2294.
PMID: 28463226
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Aberdam et al. (2017), Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing PLoS ONE, 12(6):e0179913.
PMID: 28640863
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KW McCracken et al. (2017), Wnt/?-catenin promotes gastric fundus specification in mice and humans Nature, 0(0):.
PMID: 28052057
Applications: Western Blot

I Wagner et al. (2017), Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration Dev. Cell, 40(6):608-617.e6.
PMID: 28350991
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Rahman et al. (2017), Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence Nat Commun, 8(0):15380.
PMID: 28541275
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Campbell et al. (2017), Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration Sci Rep, 7(1):3978.
PMID: 28638124
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Xing et al. (2017), In Vitro Micropatterned Human Pluripotent Stem Cell Test (ï¿½P-hPST) for Morphometric-Based Teratogen Screening Sci Rep, 7(1):8491.
PMID: 28819231
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Yucer et al. (2017), Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Sci Rep, 7(1):10741.
PMID: 28878359
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Choudhury et al. (2017), Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 7(0):41238.
PMID: 28120901
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HK Voges et al. (2017), Development of a human cardiac organoid injury model reveals innate regenerative potential Development, 0(0):.
PMID: 28174241
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Chattopadh et al. (2017), Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway Biofactors, 0(0):.
PMID: 28186649
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Tiburcy et al. (2017), Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair Circulation, 135(19):1832-1847.
PMID: 28167635
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KM Tsang et al. (2017), Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1? Stem Cell Reports, 0(0):.
PMID: 28781077
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Jung et al. (2017), In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells Nat Commun, 8(0):15680.
PMID: 28604658
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AG Kotini et al. (2017), Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia Cell Stem Cell, 0(0):.
PMID: 28215825
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KB McCauley et al. (2017), Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 0(0):.
PMID: 28366587
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AG Freire et al. (2017), Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate Stem Cell Reports, 0(0):.
PMID: 28648899
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JH Lee et al. (2017), Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations Cell Stem Cell, 21(2):179-194.e4.
PMID: 28777944
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

K Breckwoldt et al. (2017), Differentiation of cardiomyocytes and generation of human engineered heart tissue Nat Protoc, 12(6):1177-1197.
PMID: 28492526
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Kumar et al. (2017), Induction of senescence in primary glioblastoma cells by serum and TGF? Sci Rep, 7(1):2156.
PMID: 28526854
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Low et al. (2017), Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System Stem Cell Reports, 0(0):.
PMID: 28457888
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Yamamizu et al. (2017), Inï¿½Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling Stem Cell Reports, 0(0):.
PMID: 28238797
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Krendl et al. (2017), GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency Proc. Natl. Acad. Sci. U.S.A., 0(0):.
PMID: 29078328
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NJ Palpant et al. (2017), Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis Cell Rep, 20(7):1597-1608.
PMID: 28813672
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Shao et al. (2017), A pluripotent stem cell-based model for post-implantation human amniotic sac development Nat Commun, 8(1):208.
PMID: 28785084
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JH Lee et al. (2017), Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency Cell Rep, 19(1):20-35.
PMID: 28380358
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Kojima et al. (2017), Efficient production of trophoblast lineage cells from human induced pluripotent stem cells Lab. Invest, 0(0):.
PMID: 28287635
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LA Ahrens et al. (2017), Gelatin device for the delivery of growth factors involved in endochondral ossification PLoS ONE, 12(4):e0175095.
PMID: 28380024
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JP Matson et al. (2017), Rapid DNA replication origin licensing protects stem cell pluripotency Elife, 6(0):.
PMID: 29148972
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Sampazioti et al. (2017), Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells Nat Protoc, 12(4):814-827.
PMID: 28333915
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AA Mody et al. (2017), Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-?2 in Human TM Cells Invest. Ophthalmol. Vis. Sci, 58(2):849-859.
PMID: 28159972
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Jeziorowsk et al. (2017), Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols Int J Mol Sci, 18(6):.
PMID: 28587156
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ampuja et al. (2017), Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer BMC Genomics, 18(1):68.
PMID: 28077088
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Tachida et al. (2017), Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 6(3):370-380.
PMID: 28298363
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Taguchi et al. (2017), Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 0(0):.
PMID: 29129523
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

R McLennan et al. (2017), DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion J. Cell Biol., 216(10):3339-3354.
PMID: 28811280
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Warrier et al. (2017), Direct comparison of distinct naive pluripotent states in human embryonic stem cells Nat Commun, 8(0):15055.
PMID: 28429706
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2017), Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium Stem Cell Reports, 0(0):.
PMID: 29107590
Species: Zebrafish
Sample Types: Whole Tissue
Applications: Bioassay

OH Ocaña et al. (2017), A right-handed signalling pathway drives heart looping in vertebrates Nature, 549(7670):86-90.
PMID: 28880281
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LK Bollum et al. (2017), BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5 PLoS ONE, 12(5):e0177188.
PMID: 28489883
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage Stem Cells, 0(0):.
PMID: 27571517
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Medial HOXA genes demarcate haematopoietic stem cell fate during human development Nat Cell Biol, 0(0):.
PMID: 27183470
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mariko Horii (2016), Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease Proc Natl Acad Sci USA, 0(0):.
PMID: 27325764
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huang-Tian Yang (2016), Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells Purinergic Signal., 12(3):465-78.
PMID: 27098757
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker Nat. Biotechnol, 0(0):.
PMID: 27941801
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Kadota et al. (2016), Inï¿½Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts Stem Cell Reports, 0(0):.
PMID: 28065644
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves EBioMedicine, 10(0):282-90.
PMID: 27394642
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Zeltner et al. (2016), Capturing the biology of disease severity in a PSC-based model of familial dysautonomia Nat. Med., 22(12):1421-1427.
PMID: 27841875
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robert Thomas (2016), Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation Biotechnol. Prog., 32(1):215-23.
PMID: 26560993
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9) PLoS ONE, 11(11):e0166382.
PMID: 27875556
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation Stem Cell Res, 17(2):222-227.
PMID: 27591478
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

G B de Souza (2016), Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro Reprod. Domest. Anim, 0(0):.
PMID: 27925309
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes Stem Cell Reports, 0(0):.
PMID: 27569062
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling Stem Cell Res Ther, 7(1):115.
PMID: 27530160
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients Elife, 5(0):.
PMID: 27458797
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway Cell Biosci, 6(1):50.
PMID: 27583127
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Christine Kestens et al. (2016), BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2. PLoS ONE, 0(0):1932-6203.
PMID: 27191723
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hermanson D et al. (2016), Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells, 34(1):93-101.
PMID: 26503833
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 11(12):e0168334.
PMID: 27977771
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells EMBO Mol Med, 0(0):.
PMID: 27470144
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IA Song et al. (2016), The involvement of protein kinase C-? in isoflurane induced preconditioning of human embryonic stem cell--derived Nkx2.5(+) cardiac progenitor cells BMC Anesthesiol, 16(0):13.
PMID: 26897636
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Five colour variants of bright luminescent protein for real-time multicolour bioimaging Nat Commun, 7(0):13718.
PMID: 27966527
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Olivier Abbo (2016), Comparison between pediatric and adult adipose mesenchymal stromal cells Cytotherapy, 0(0):.
PMID: 28040462
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Irene De Almeida (2016), Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction Dev. Biol, 0(0):.
PMID: 27919666
Sample Types: Protein
Applications: Bioassay

Arnold Junior Tatsinkam (2016), The Binding of the Bone Morphogenetic Protein Antagonist Gremlin to Kidney Heparan Sulfate: Such Binding is not Essential for BMP Antagonism Int. J. Biochem. Cell Biol, 0(0):.
PMID: 27979781
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes Stem Cells Transl Med, 0(0):.
PMID: 27591141
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells Sci Rep, 6(0):31063.
PMID: 27507707
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells Nat Commun, 7(0):13602.
PMID: 27934856
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Duggal G et al. (2015), Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells. Stem Cells, 33(9):2686-98.
PMID: 26108678
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim J et al. (2015), BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells. Mol Cancer, 14(1):173.
PMID: 26395571
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kim M et al. (2015), Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS ONE, 10(2):e0118670.
PMID: 25706534
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gerbin K et al. (2015), Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts. PLoS ONE, 10(7):e0131446.
PMID: 26161513
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Iyer D et al. (2015), Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development, 142(8):1528-41.
PMID: 25813541
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Gottle P et al. (2015), Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci, 35(3):906-19.
PMID: 25609610
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wong S et al. (2015), Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Cancer Res, 75(6):1113-22.
PMID: 25634210
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Song B et al. (2015), Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. Stem Cells Dev, 24(9):1053-65.
PMID: 25517294
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lee J et al. (2015), Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells, 33(4):1142-52.
PMID: 25639500
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Muller P et al. (2015), Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. PLoS ONE, 10(7):e0131467.
PMID: 26173116
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tadeu A et al. (2015), Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. PLoS ONE, 10(4):e0122493.
PMID: 25849374
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tate C et al. (2015), A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE, 10(4):e0125697.
PMID: 25919028
Kitajima K et al. (2015), GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol, 44(1):68-74.e10.
PMID: 26477526
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maury Y et al. (2015), Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol, 33(1):89-96.
PMID: 25383599
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tsankov et al. (2015), Transcription factor binding dynamics during human ES cell differentiation. Nature, 518(7539):344-9.
PMID: 25693565
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sugawa F et al. (2015), Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. EMBO J, 34(8):1009-24.
PMID: 25750208
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wu J et al. (2015), Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells. Stem Cells Dev, 24(7):892-903.
PMID: 25405279
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Craft A et al. (2015), Generation of articular chondrocytes from human pluripotent stem cells. Nat Biotechnol, 33(6):638-45.
PMID: 25961409
Species: Chicken
Sample Types: Whole Organism
Applications: In Vivo

Hu D et al. (2015), A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Development, 142(3):567-74.
PMID: 25605783
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wong et al. (2015), Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc, 10(3):363-81.
PMID: 25654755
Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Gori J et al. (2015), Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest, 125(3):1243-54.
PMID: 25664855
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Ray P et al. (2015), Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling. PLoS ONE, 10(8):e0134702.
PMID: 26237312
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nio-Kobayashi J et al. (2015), Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology, 156(4):1494-503.
PMID: 25635621
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huang S et al. (2015), The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 10(3):413-25.
PMID: 25654758
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Majumder A et al. (2015), Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem, 290(21):13053-63.
PMID: 25847244
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yang Y et al. (2015), Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. Proc Natl Acad Sci U S A, 112(18):E2337-46.
PMID: 25870291
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fang F et al. (2014), The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function. J Cell Sci, 127(0):1428-40.
PMID: 24463812
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Lorda-Diez C et al. (2014), Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res, 29(3):735-48.
PMID: 24038612
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ronaghi et al. (2014), Inner ear hair cell-like cells from human embryonic stem cells. Stem Cells Dev, 23(11):1275-84.
PMID: 24512547
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mahadevan et al. (2014), NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation. Hum Mol Genet, 23(3):706-16.
PMID: 24105472
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takebe et al. (2014), Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc, 9(2):396-409.
PMID: 24457331
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huang et al. (2014), Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 32(1):84-91.
PMID: 24291815
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lee et al. (2014), Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep, 4(0):6319.
PMID: 25204726
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Josowitz et al. (2014), Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression. PLoS ONE, 9(7):e101316.
PMID: 25010565
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Mann Z et al. (2014), A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun, 5(0):3839.
PMID: 24845721
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Watanabe et al. (2014), HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS ONE, 9(3):e90791.
PMID: 24651531
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takayama K et al. (2014), CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision. Development, 141(1):91-100.
PMID: 24284203
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Culbert A et al. (2014), Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells, 32(5):1289-300.
PMID: 24449086
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Olsen O et al. (2014), Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J, 4(0):e196.
PMID: 24658374
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chang C et al. (2014), Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells. PLoS ONE, 9(5):e97335.
PMID: 24828440
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takahashi K et al. (2014), Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm. Nat Commun, 5(0):3678.
PMID: 24759836
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Turnbull I et al. (2014), Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB J, 28(2):644-54.
PMID: 24174427
Cao Y et al. (2014), BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity. Cancer Res, 74(18):5091-102.
PMID: 25224959
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lam A et al. (2014), Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 25(6):1211-25.
PMID: 24357672
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ohnuma et al. (2014), Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep, 4(0):4646.
PMID: 24721898
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Luo J et al. (2014), Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med, 3(6):734-44.
PMID: 24736402
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tsuchida et al. (2014), BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene, 33(29):3803-11.
PMID: 24013228
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tolar J et al. (2014), Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 134(5):1246-54.
PMID: 24317394
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Todaro M et al. (2014), CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 14(3):342-56.
PMID: 24607406
Kim W et al. (2014), Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells, 32(6):1503-14.
PMID: 24677652
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yang et al. (2014), Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. Nat Commun, 5(0):3071.
PMID: 24468981
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yamada et al. (2014), Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS ONE, 9(2):e89135.
PMID: 24586548
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lim M et al. (2014), Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. PLoS ONE, 9(9):e107712.
PMID: 25229469
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shelton M et al. (2014), Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Stem Cell Reports, 3(3):516-29.
PMID: 25241748
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ferrell et al. (2014), Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev, 23(12):1355-63.
PMID: 24517837
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Taguchi A et al. (2014), Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell, 14(1):53-67.
PMID: 24332837
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jakobsen R et al. (2014), Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE, 9(5):e96615.
PMID: 24816923
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Zhang Y et al. (2014), Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler Thromb Vasc Biol, 34(1):152-9.
PMID: 24202302
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kondo T et al. (2014), Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports, 3(2):242-9.
PMID: 25254338
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jiang D et al. (2014), MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-beta1/SMAD5 signaling module. Blood, 123(1):86-93.
PMID: 24136167
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Laperrousaz B et al. (2014), Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood, 122(23):3767-77.
PMID: 24100446
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dominguez et al. (2014), Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies. Sci Rep, 4(0):6432.
PMID: 25242416
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Morishima et al. (2014), Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica, 99(1):19-27.
PMID: 23975175
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kobayashi et al. (2014), Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome. PLoS ONE, 9(7):e102796.
PMID: 25050861
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Ao et al. (2014), High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE, 9(6):e100417.
PMID: 24949734
Srikanth et al. (2014), BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol Cancer Res, 12(2):283-94.
PMID: 24269952
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lin et al. (2014), Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports, 2(2):189-204.
PMID: 24527393
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wile B et al. (2014), Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc, 9(10):2411-24.
PMID: 25232937
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Park et al. (2014), Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc Natl Acad Sci U S A, 111(25):9253-8.
PMID: 24927536
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Xue et al. (2014), Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Am J Physiol Endocrinol Metab, 306(4):E363-72.
PMID: 24347060
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

Cabrera-Sharp V et al. (2014), SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion. Endocrinology, 155(8):3054-64.
PMID: 24848867
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Talavera-Adame et al. (2013), Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev, 22(24):3252-60.
PMID: 23924071
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hannan et al. (2013), Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc, 8(2):430-7.
PMID: 23370178
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reinhardt P et al. (2013), Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE, 8(3):e59252.
PMID: 23533608
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Goldman O et al. (2013), KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell, 12(6):748-60.
PMID: 23746980
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Goyal et al. (2013), Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies. PLoS ONE, 8(12):e82838.
PMID: 24349377
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Doulatov S et al. (2013), Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell, 13(4):459-70.
PMID: 24094326
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Glister C et al. (2013), Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A, 110(15):E1426-35.
PMID: 23530236
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Navarrete E et al. (2013), Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation, 128(11):S3-13.
PMID: 24030418
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Higurashi N et al. (2013), A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain, 6(0):19.
PMID: 23639079
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kawabata K et al. (2013), TGF-beta-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20. Oncogene, 32(16):2096-106.
PMID: 22665052
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fujiwara et al. (2013), A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS ONE, 8(9):e75568.
PMID: 24086573
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vrijens K et al. (2013), Identification of small molecule activators of BMP signaling. PLoS ONE, 8(3):e59045.
PMID: 23527084
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

White M et al. (2013), Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells, 31(1):92-103.
PMID: 23079999
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Gu L et al. (2013), Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest, 93(4):450-61.
PMID: 23439432
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chou H et al. (2013), BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS ONE, 8(3):e58441.
PMID: 23472198
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takayama K et al. (2013), Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports, 1(4):322-35.
PMID: 24319667
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Kohler et al. (2013), Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells. PLoS ONE, 8(12):e85549.
PMID: 24386480
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pick M et al. (2013), Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium. PLoS ONE, 8(2):e55530.
PMID: 23424635
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Liang et al. (2013), Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation, 127(16):1677-91.
PMID: 23519760
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Duggal G et al. (2013), Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential. Stem Cells Dev, 22(23):3141-55.
PMID: 23829223
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Deschaseaux F et al. (2013), Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J, 27(8):2977-87.
PMID: 23592762
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang Y et al. (2013), Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell, 25(1):69-80.
PMID: 23541921
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lee J et al. (2013), Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2(0):e00940.
PMID: 24252877
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay

Kim M et al. (2012), Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE, 7(4):e35100.
PMID: 22514712
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012), Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 19(10):1035-40.
PMID: 22071967
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Wu et al. (2012), Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 7(9):e46307.
PMID: 23029472
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cheung C et al. (2012), Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat. Biotechnol., 30(2):165-73.
PMID: 22252507
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Joubin et al. (2012), The endothelial cell line bEnd.3 maintains human pluripotent stem cells. Stem Cells Dev, 21(12):2312-21.
PMID: 22224974
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Aad et al. (2012), The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 87(4):79.
PMID: 22811575
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Yao Y et al. (2012), Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood, 119(21):5037-47.
PMID: 22474252
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huse K et al. (2012), Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 7(10):e46117.
PMID: 23049692
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pereira P et al. (2012), Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development, 139(18):3343-54.
PMID: 22912414
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wong RC et al. (2011), A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Stem Cells, 29(10):1517-27.
PMID: 21898682
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huse K et al. (2011), Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur. J. Immunol., 41(11):3135-45.
PMID: 21898381
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rochira JA et al. (2011), A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-kappaB activation and apoptosis in P19 cells. PLoS ONE, 6(7):e20659.
PMID: 21789165
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Davis-Dusenbery BN et al. (2011), Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J. Biol. Chem., 286(32):28097-110.
PMID: 21673106
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Castonguay R et al. (2011), Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 286(34):30034-46.
PMID: 21737454
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Geens M et al. (2011), Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J. Assist. Reprod. Genet., 0(0):.
PMID: 21318592
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang Q et al. (2011), Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res., 21(4):579-87.
PMID: 21102549
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maegdefrau U et al. (2011), Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma. Lab. Invest., 91(11):1615-23.
PMID: 21863061
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Niwa A et al. (2011), A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 6(7):e22261.
PMID: 21818303
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tolar J et al. (2011), Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood, 117(3):839-47.
PMID: 21037085
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chng Z et al. (2010), SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell, 6(1):59-70.
PMID: 20074535
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Roelandt P et al. (2010), Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 5(8):e12101.
PMID: 20711405
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Martino MM et al. (2010), The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J., 24(12):4711-21.
PMID: 20671107
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lanner F et al. (2010), Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells, 28(2):191-200.
PMID: 19937756
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rai D et al. (2010), Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc. Natl. Acad. Sci. U.S.A., 107(7):3111-6.
PMID: 20133617
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Klim JR et al. (2010), A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat. Methods, 7(12):989-94.
PMID: 21076418
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Grcevic D et al. (2010), Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leuk. Res., 34(6):742-51.
PMID: 19926132
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stewart A et al. (2010), BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway. J. Cell. Physiol., 223(3):658-66.
PMID: 20143330
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Stevens KR et al. (2009), Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A, 15(6):1211-22.
PMID: 19063661
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Herrera B et al. (2009), A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 10(0):20.
PMID: 19298647
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bernardo AS et al. (2009), Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells, 27(2):341-51.
PMID: 19056911
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tanno T et al. (2009), Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood, 114(1):181-6.
PMID: 19414861
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kelly MA et al. (2009), Signaling hierarchy regulating human endothelial cell development. Arterioscler. Thromb. Vasc. Biol., 29(5):718-24.
PMID: 19213939
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sugiura K et al. (2009), Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol. Reprod., 81(5):833-41.
PMID: 19553596
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Sellers DL et al. (2009), Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J. Neurosci., 29(20):6722-33.
PMID: 19458241
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

Levine AJ et al. (2009), GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev. Biol., 325(1):43-8.
PMID: 18823971
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ye L et al. (2009), Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 106(24):9826-30.
PMID: 19482945
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Anderson BC et al. (2008), Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus. Invest. Ophthalmol. Vis. Sci., 49(1):221-9.
PMID: 18172096
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Desbordes SC et al. (2008), High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2(6):602-12.
PMID: 18522853
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Elkabetz Y et al. (2008), Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 22(2):152-65.
PMID: 18198334
Species: Human
Sample Types: Cell Lysates
Applications: Binding Assay

Kane R et al. (2008), Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol. Vis., 14(0):1138-48.
PMID: 18587495
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay

Sengle G et al. (2008), Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 283(20):13874-88.
PMID: 18339631
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Saeki K et al. (2008), Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells. J. Cell. Physiol., 217(1):261-80.
PMID: 18551514
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wu Z et al. (2008), Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J. Biol. Chem., 283(36):24991-5002.
PMID: 18596037
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sun Y et al. (2008), Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol. Cell. Neurosci., 38(2):245-58.
PMID: 18450476
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Boswell BA et al. (2008), Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev. Biol., 324(2):202-12.
PMID: 18848538
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yang L et al. (2008), Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature, 453(7194):524-8.
PMID: 18432194
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Southwood M et al. (2008), Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 214(1):85-95.
PMID: 17992660
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jeanpierre S et al. (2008), BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 112(8):3154-63.
PMID: 18664625
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Boswell BA et al. (2008), Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol. Cell, 19(6):2631-41.
PMID: 18400943
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tseng YH et al. (2008), New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 454(7207):1000-4.
PMID: 18719589
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chen G et al. (2008), Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell, 2(4):345-55.
PMID: 18397754
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Yao Y et al. (2008), High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler. Thromb. Vasc. Biol., 28(12):2266-74.
PMID: 18948634
Sample Types: Whole Cells
Applications: Bioassay

Zilberberg L et al. (2007), A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol, 8(0):41.
PMID: 17880711
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lin L et al. (2007), Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 110(6):2182-9.
PMID: 17540841
Fuller ML et al. (2007), Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 62(3):288-300.
PMID: 17696121
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stabile H et al. (2007), Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood, 109(5):1834-40.
PMID: 17077323
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takahashi K et al. (2007), Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5):861-72.
PMID: 18035408
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Kavanagh KD et al. (2007), Predicting evolutionary patterns of mammalian teeth from development. Nature, 449(7161):427-32.
PMID: 17898761
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tesar PJ et al. (2007), New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 448(7150):196-9.
PMID: 17597760
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stavridis MP et al. (2007), A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development, 134(16):2889-94.
PMID: 17660197
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Knobloch J et al. (2007), Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J., 21(7):1410-21.
PMID: 17283219
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zode GS et al. (2007), Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest. Ophthalmol. Vis. Sci., 48(11):5058-67.
PMID: 17962458
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang P et al. (2007), Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 111(4):1933-41.
PMID: 18042803
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rajesh</LastName><ForeNam D</Initial et al. (2007), Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 25(2):490-9.
PMID: 17284653
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Spicer LJ et al. (2006), Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. J. Endocrinol., 189(2):329-39.
PMID: 16648300
Species: Primate - Callitrix jacchus (Common Marmoset)
Sample Types: Whole Cells
Applications: Bioassay

Kurita R et al. (2006), Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 24(9):2014-22.
PMID: 16728561
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lindsley RC et al. (2006), Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 133(19):3787-96.
PMID: 16943279
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay

Maeshima A et al. (2006), Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 295(2):473-85.
PMID: 16643884
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ikeya M et al. (2006), Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development, 133(22):4463-73.
PMID: 17035289
Species: Chicken
Sample Types: In Ovo
Applications: In Ovo

Bonafede A et al. (2006), BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol., 299(2):330-44.
PMID: 17005177
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Zeng L et al. (2006), Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 24(11):2355-66.
PMID: 16931778
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yao S et al. (2006), Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. U.S.A., 103(18):6907-12.
PMID: 16632596
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kiyono M et al. (2006), Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene, 25(54):7131-7.
PMID: 16732319
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

Holzschuh J et al. (2005), Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development, 132(16):3731-42.
PMID: 16077092
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

Reversade B et al. (2005), Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell, 123(6):1147-60.
PMID: 16360041
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

Ng RK et al. (2005), Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc. Natl. Acad. Sci. U.S.A., 102(6):1957-62.
PMID: 15684086
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Althini S et al. (2004), Blocked MAP kinase activity selectively enhances neurotrophic growth responses. Mol. Cell. Neurosci., 25(2):345-54.
PMID: 15019950
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Wakamatsu Y et al. (2004), Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development. Dev. Dyn., 229(1):74-86.
PMID: 14699579
Species: Human

Applications: Bioassay

Oren A et al. (2004), hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene, 331(0):17-31.
PMID: 15094188
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Blair DG et al. (2004), Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol., 173(10):5914-7.
PMID: 15528323
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Marklund M et al. (2004), Retinoic acid signalling specifies intermediate character in the developing telencephalon. Development, 131(17):4323-32.
PMID: 15294870
Species: Ovine
Sample Types: Whole Cells
Applications: Bioassay

Pierre A et al. (2004), Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells. J. Mol. Endocrinol., 33(3):805-17.
PMID: 15591037
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Binnerts ME et al. (2004), Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun., 315(2):272-80.
PMID: 14766204
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Moser M et al. (2003), BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 23(16):5664-79.
PMID: 12897139
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Viti J et al. (2003), Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci., 23(13):5919-27.
PMID: 12843296
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Ahn SH et al. (2003), Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. J. Periodontol., 74(6):787-97.
PMID: 12886988
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Fischer A et al. (2002), FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr. Biol., 12(21):1807-16.
PMID: 12419180
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In Kyoung Mah et al. (0), Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation. Dev Bio416(1):82-97.
PMID: 27312576

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Recombinant Human BMP-4 Protein

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Recombinant Human BMP-4 Protein

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Recombinant Human BMP-4 Protein

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FAQs

What is the half-life of a recombinant or natural protein in culture at 37 °C?

R&D Systems has not determined the half-life of recombinant or natural proteins in culture. For cell-based bioassays, the incubation period of the protein with the cells typically ranges from 48 to 96 hours. Assay conditions for each protein will need to be optimized by each researcher.
Can Recombinant Human BMP-4 Protein (Catalog # 314-BP or 314-BP/CF) be reconstituted in PBS or water?

Recombinant Human BMP-4 (Catalog # 314-BP or 314-BP/CF) needs to be reconstituted to 50-200 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl to ensure optimal recovery, stability, and activity. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

Recombinant Human BMP-4 Protein

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Recombinant Human BMP-4 Protein

Recombinant Human BMP-4 Protein

Recombinant Human BMP-4 Protein

Recombinant Human BMP-4 Protein

Recombinant Human BMP-4 Protein

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