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Wnt-3a: Proteins and Enzymes

Wnt-3a is a secreted protein that is necessary for proper embryonic development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. It also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. The post-translational glycosylation and acylation of Wnts are essential for their efficient secretion and biological activity, respectively. Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta-catenin levels. As intracellular beta-catenin levels rise, beta-catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes.

8 results for "Wnt-3a Proteins and Enzymes" in Products

Wnt-3a: Proteins and Enzymes

Wnt-3a is a secreted protein that is necessary for proper embryonic development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. It also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. The post-translational glycosylation and acylation of Wnts are essential for their efficient secretion and biological activity, respectively. Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta-catenin levels. As intracellular beta-catenin levels rise, beta-catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes.

8 results for "Wnt-3a Proteins and Enzymes" in Products

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Catalog #: PSM5036
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Recombinant Human Wnt-3a (10 ug), Wnt Pathway Inhibitor (endo-IWR 1), and Control Compound (exo-IWR 1)

Catalog #: 1324-WNP
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Catalog #: PSM1324
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Recombinant Mouse Wnt-3a (2 ug), Wnt Pathway Inhibitor (endo-IWR 1), and Control Compound (exo-IWR 1)

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