Small Molecules and Peptides (13)
Small Molecules (12)
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Inhibitor (12)
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Tocris Bioscience (13)
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13 results for "Rho-kinase Inhibitors Small Molecules and Peptides" in Products

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Rho-kinase Inhibitors Small Molecules and Peptides

Y-27632 dihydrochloride
Catalog #: 1254
(19)
Citations (1869)
Product Documents
Images (8)

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

GMP Version Available: TB1254-GMP
GMP
Alternate Names:
y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
Chemical Name:
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity:
≥98%
ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm,
(8)
Catalog #
Availability
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Qty
1254/50
1254/10
1254/1
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Y-27632 dihydrochlorideGMP

Catalog #: TB1254-GMP
Citations (19)
Product Documents
Images (1)

Y-27632 synthesized to cGMP guidelines

Chemical Name:
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity:
≥99%
Y-27632 synthesized to cGMP guidelines
Catalog #
Availability
Size / Price
Qty
TB1254-GMP/10
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Chroman 1
Catalog #: 7163
Citations (34)
Product Documents
Images (1)

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name:
(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity:
≥98%
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
Catalog #
Availability
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Qty
7163/10
7163/50
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H 1152 dihydrochloride
Catalog #: 2414
(4)
Citations (38)
Product Documents
Images (1)

Selective Rho-kinase (ROCK) inhibitor

Chemical Name:
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Purity:
≥98%
Selective Rho-kinase (ROCK) inhibitor
Catalog #
Availability
Size / Price
Qty
2414/1
Bulk Order

Fasudil hydrochloride
Catalog #: 0541
Citations (34)
Product Documents
Images (1)

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

Alternate Names:
HA 1077
Purity:
≥98%
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
Catalog #
Availability
Size / Price
Qty
0541/10
0541/50
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GSK 269962
Catalog #: 4009
Citations (35)
Product Documents
Images (1)

Potent and selective ROCK inhibitor

Chemical Name:
N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Purity:
≥98%
Potent and selective ROCK inhibitor
Catalog #
Availability
Size / Price
Qty
4009/10
4009/50
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Glycyl-H 1152 dihydrochloride
Catalog #: 2485
Citations (9)
Product Documents
Images (1)

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Chemical Name:
(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Purity:
≥98%
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Catalog #
Availability
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Qty
2485/1
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SB 772077B dihydrochloride
Catalog #: 4118
Citations (1)
Product Documents
Images (1)

Potent Rho-kinase inhibitor; vasodilator

Chemical Name:
(3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride
Purity:
≥98%
Potent Rho-kinase inhibitor; vasodilator
Catalog #
Availability
Size / Price
Qty
4118/50
4118/10
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TC-S 7001
Catalog #: 4961
Citations (6)
Product Documents
Images (1)

Potent and highly selective ROCK inhibitor; orally active

Alternate Names:
Azaindole-1,BAY-549
Chemical Name:
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Purity:
≥98%
Potent and highly selective ROCK inhibitor; orally active
Catalog #
Availability
Size / Price
Qty
4961/1
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RKI 1447 dihydrochloride
Catalog #: 5061
Citations (2)
Product Documents
Images (1)

Potent and selective ROCK inhibitor; antitumor

Chemical Name:
N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride
Purity:
≥98%
Potent and selective ROCK inhibitor; antitumor
Catalog #
Availability
Size / Price
Qty
5061/50
5061/10
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OXA 06 dihydrochloride
Catalog #: 5182
Citations (1)
Product Documents
Images (1)

Potent ROCK inhibitor

Chemical Name:
2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
Purity:
≥98%
Potent ROCK inhibitor
Catalog #
Availability
Size / Price
Qty
5182/50
5182/10
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Y-27632 in solution
Catalog #: 7000
(1)
Product Documents
Images (2)

Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water

Chemical Name:
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity:
≥97%
vial of Y-27632 in solution
(2)
Catalog #
Availability
Size / Price
Qty
7000/4
Bulk Order

CHDI 00580985
Catalog #: 7881
Product Documents
Images (1)

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

Chemical Name:
(2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
Purity:
≥98%
Potent and selective ROCK2 inhibitor; orally bioavailable and brain penetrant
Catalog #
Availability
Size / Price
Qty
7881/10
Bulk Order
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