Glycyl-H 1152 dihydrochloride

Name: Glycyl-H 1152 dihydrochloride
Brand: Tocris Bioscience
SKU: 2485

Tocris Bioscience, part of Bio-Techne | Catalog # 2485

Citations (12)

COA / SDS

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Key Product Details

Description:	Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Chemical Name:	(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	449.4

View Full Technical Details for Glycyl-H 1152 dihydrochloride

Technical Data
Citations

Biological Activity for Glycyl-H 1152 dihydrochloride

Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC₅₀ values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data for Glycyl-H 1152 dihydrochloride

M. Wt	449.4
Formula	C₁₈H₂₄N₄O₃S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	913844-45-8
PubChem ID	56972177
InChi Key	ILDBNQGLZFSHQZ-UTLKBRERSA-N
Smiles	CC1=CN=CC2=C1C(S(N3CCCN(C(CN)=O)C[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Glycyl-H 1152 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.94	100
	DMSO	22.47	50

Preparing Stock Solutions for Glycyl-H 1152 dihydrochloride

The following data is based on the product molecular weight 449.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.13 mL	22.25 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for Glycyl-H 1152 dihydrochloride

References are publications that support the biological activity of the product.

Tamura Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 2005 PMID: 16213195