H 1152 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2414

Selective Rho-kinase (ROCK) inhibitor
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Key Product Details

Description

Selective Rho-kinase (ROCK) inhibitor

View all Rho-kinase Inhibitors »

Product Description

H 1152 dihydrochloride is a rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats.

Glycyl Derivative also available.

Product Specifications

Molecular Weight

392.34

Formula

C16H21N3O2S.2HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

CAS Number

871543-07-6

PubChem ID

11560225

InChI Key

BFOPDSJOLUQULZ-GXKRWWSZSA-N

SMILES

CC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.23 100
DMSO 19.62 50

Preparing Stock Solutions for H 1152 dihydrochloride

The following data is based on the product molecular weight 392.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.10 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for H 1152 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H 1152 dihydrochloride

For research use only

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