OXA 06 dihydrochloride

Name: OXA 06 dihydrochloride
Brand: Tocris Bioscience
SKU: 5182

Tocris Bioscience, part of Bio-Techne | Catalog # 5182

Citations (2)

COA / SDS

Potent ROCK inhibitor

Key Product Details

Description:	Potent ROCK inhibitor
Chemical Name:	2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	404.31

View Full Technical Details for OXA 06 dihydrochloride

Technical Data
Citations

Biological Activity for OXA 06 dihydrochloride

OXA 06 dihydrochloride is a potent ROCK inhibitor (IC₅₀ = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.

Technical Data for OXA 06 dihydrochloride

M. Wt	404.31
Formula	C₂₁H₁₈FN₃.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1825455-91-1
PubChem ID	91691120
InChi Key	ZRBCUSMZOWMVJS-UHFFFAOYSA-N
Smiles	FC1=CC=CC=C1CNCC(C=C4)=CC=C4C2=C3C(NC=C3)=NC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OXA 06 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.43	100

Preparing Stock Solutions for OXA 06 dihydrochloride

The following data is based on the product molecular weight 404.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.37 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for OXA 06 dihydrochloride

References are publications that support the biological activity of the product.

Vigil ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 2012 PMID: 22942252