TC-S 7001
Tocris Bioscience, part of Bio-Techne | Catalog # 4961
Potent and highly selective ROCK inhibitor; orally active
Key Product Details
Description
Potent and highly selective ROCK inhibitor; orally active
Alternative Names
Azaindole-1,BAY-549
Product Description
TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of TC-S 7001 (BAY 549) is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
402.79
Formula
C18H13ClF2N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
CAS Number
867017-68-3
PubChem ID
11524200
InChI Key
NRSGWEVTVGZDFC-UHFFFAOYSA-N
SMILES
ClC1=CC(NC2=CC(F)=C(OC3=C(C(C)=CN4)C4=NC=C3)C(F)=C2)=NC(N)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.28 | 100 | |
| Ethanol | 40.28 | 100 |
Preparing Stock Solutions
for TC-S 7001
The following data is based on the product molecular weight 402.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.83 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dahal Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. Eur.Resp.J. 2010 PMID: 20530035
- Kast Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br.J.Pharmacol. 2007 PMID: 17934515
Product Specific Notices for TC-S 7001
For research use only
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