CHDI 00580985
Tocris Bioscience, part of Bio-Techne | Catalog # 7881
Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant
Key Product Details
Description
Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant
Product Description
CHDI 00580985 is a potent and selective ROCK inhibitor (IC50 values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC50 = 4 nM). In vivo, CHDI 00580985 reduces ROCK signaling in Huntington's disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.Licensing Information
Sold under license from CHDI FoundationProduct Specifications
Molecular Weight
372.44
Formula
C20H25FN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
CAS Number
2573071-18-6
PubChem ID
155749520
InChI Key
CIPXFTLGPVQJKN-HUUCEWRRSA-N
SMILES
FC1=CN=CC=C1N2C[C@H](N(CC2)C(N[C@@H](C3=CC(OC)=CC=C3)C)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 | |
| Ethanol | 37.24 | 100 |
Preparing Stock Solutions
for CHDI 00580985
The following data is based on the product molecular weight 372.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ladduwahetty Identification of a potent, selective, and brain-penetrant Rho kinase inhibitor and its activity in a mouse model of Huntington's disease. J.Med.Chem. 2022 PMID: 35816678
Product Specific Notices for CHDI 00580985
For research use only
Loading...
Loading...