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467 results for "MDM2/HDM2" in Products

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MDM2/HDM2 Products

MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.

MDM2/HDM2 Antibody (SMP14) - BSA Free
Catalog #: NB100-2736
(1)
Citations (24)
Product Documents
Images (3)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG1 kappa Monoclonal Clone #SMP14
Applications:
IHC, WB, IP
Western Blot: MDM2/HDM2 Antibody (SMP14)BSA Free [NB100-2736]
(3)
Catalog #
Availability
Size / Price
Qty
NB100-2736
NB100-2736SS
Bulk Order

MDM2/HDM2 Antibody
Catalog #: AF1244
Citations (35)
Product Documents
Images (12)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
(12)
Catalog #
Availability
Size / Price
Qty
AF1244-SP
AF1244
Bulk Order

Human MDM2/HDM2 Antibody (197702)
Catalog #: MAB1244
(3)
Citations (1)
Product Documents
Images (1)
Reactivity:
Human
Details:
Mouse IgG2B Monoclonal Clone #197702
Applications:
IP
Immunoprecipitation of Human MDM2.
Catalog #
Availability
Size / Price
Qty
MAB1244
MAB1244-SP
Bulk Order

MDM2/HDM2 Antibody (SMP14) - Azide and BSA Free
Catalog #: NBP2-80845
Product Documents
Images (3)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG1 kappa Monoclonal Clone #SMP14
Applications:
IHC, WB, IP
Western Blot: MDM2/HDM2 Antibody (SMP14)Azide and BSA Free [NBP2-80845]
(3)
Catalog #
Availability
Size / Price
Qty
NBP2-80845
Bulk Order

Nutlin-3
Catalog #: 3984
(1)
Citations (36)
Product Documents
Images (1)

MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name:
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Purity:
≥98%
MDM2 antagonist; inhibits MDM2-p53 interaction
Catalog #
Availability
Size / Price
Qty
3984/10
3984/50
Bulk Order

MDM2/HDM2 Antibody - BSA Free
Catalog #: NBP2-17247
Citations (3)
Product Documents
Images (11)
Reactivity:
Human, Mouse
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB, ICC/IF, IP, ChIP
Western Blot: MDM2/HDM2 Antibody [NBP2-17247]
(11)
Catalog #
Availability
Size / Price
Qty
NBP2-17247
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor™ Plus 680]
Catalog #: AF1244AFP680
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244AFP680-100UG
Bulk Order

Human Total MDM2/HDM2 DuoSet IC ELISA
Catalog #: DYC1244-2
Citations (3)
Product Documents
Images (3)
Reactivity:
Human
Assay Range:
312-20000 pg/mL
Applications:
ELISA
(3)
Catalog #
Availability
Size / Price
Qty
DYC1244E
DYC1244-2
DYC1244-5
Bulk Order

MDM2/HDM2 Antibody (A10E11-R)
Catalog #: NBP3-32584
Product Documents
Images (4)

Recombinant Monoclonal Antibody

Reactivity:
Human, Monkey
Details:
Mouse IgG1 Monoclonal Clone #A10E11-R
Applications:
IHC, WB, ICC/IF
MDM2/HDM2 Antibody (A10E11-R)
(4)
Catalog #
Availability
Size / Price
Qty
NBP3-32584
Bulk Order

MDM2/HDM2 Antibody (1A7) - Azide and BSA Free
Catalog #: H00004193-M01
Product Documents
Images (5)
Reactivity:
Human
Details:
Mouse IgG1 kappa Monoclonal Clone #1A7
Applications:
IHC, WB, ELISA, Func, Mycoplasma
Western Blot: MDM2/HDM2 Antibody (1A7) [H00004193-M01]
(5)
Catalog #
Availability
Size / Price
Qty
H00004193-M01
Bulk Order

Recombinant Human MDM2/HDM2 GST-tag Protein, CF

Catalog #: 11802-DM
Product Documents
Images (2)
Reactivity:
Human
Source:
E. coli
Applications:
Bioactivity
(2)
Catalog #
Availability
Size / Price
Qty
11802-DM-025
Bulk Order

Nutlin 3a
Catalog #: 6075
Citations (23)
Product Documents
Images (1)

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Chemical Name:
4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity:
≥97%
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Catalog #
Availability
Size / Price
Qty
6075/25
6075/5
Bulk Order

MDM2/HDM2 Antibody (24GB7055)
Catalog #: NBP3-50875
Images (3)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG1 kappa Monoclonal Clone #24GB7055
Applications:
WB, Flow, ICC/IF
MDM2/HDM2 Antibody (24GB7055)
(3)
Catalog #
Availability
Size / Price
Qty
NBP3-50875-100ul
NBP3-50875-20ul
Bulk Order

HLI 373
Catalog #: 3503
Citations (4)
Product Documents
Images (1)

Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name:
5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Purity:
≥98%
Hdm2 inhibitor; activates p53-dependent transcription
Catalog #
Availability
Size / Price
Qty
3503/10
3503/50
Bulk Order

MDM2/HDM2 [p Ser166] Antibody - BSA Free
Catalog #: NBP3-05384
Product Documents
Images (2)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB
Western Blot: MDM2/HDM2 [p Ser166] AntibodyBSA Free [NBP3-05384]
(2)
Catalog #
Availability
Size / Price
Qty
NBP3-05384-20ul
NBP3-05384-100ul
Bulk Order

Human MDM2/HDM2 (AAM78554) VersaClone cDNA
Catalog #: RDC2746
Product Documents
Images (1)
Reactivity:
Human
Catalog #
Availability
Size / Price
Qty
RDC2746
Bulk Order

RITA
Catalog #: 2443
Citations (11)
Product Documents
Images (1)

MDM2-p53 interaction inhibitor

Alternate Names:
NSC 652287
Chemical Name:
5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Purity:
≥97%
MDM2-p53 interaction inhibitor
Catalog #
Availability
Size / Price
Qty
2443/1
2443/10
Bulk Order

SP 141
Catalog #: 5332
Citations (5)
Product Documents
Images (1)

High affinity MDM2 inhibitor

Chemical Name:
6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity:
≥98%
High affinity MDM2 inhibitor
Catalog #
Availability
Size / Price
Qty
5332/50
5332/10
Bulk Order

Idasanutlin
Catalog #: 6904
Citations (2)
Product Documents
Images (1)

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Chemical Name:
4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
Purity:
≥98%
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
Catalog #
Availability
Size / Price
Qty
6904/10
6904/50
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 488]
Catalog #: AF1244G
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244G-100UG
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 700]
Catalog #: AF1244N
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244N-100UG
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 647]
Catalog #: AF1244R
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244R-100UG
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 750]
Catalog #: AF1244S
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244S-100UG
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 594]
Catalog #: AF1244T
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244T-100UG
Bulk Order

MDM2/HDM2 Antibody [Alexa Fluor® 350]
Catalog #: AF1244U
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB
Catalog #
Availability
Size / Price
Qty
AF1244U-100UG
Bulk Order
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