Nutlin 3a
Tocris Bioscience, part of Bio-Techne | Catalog # 6075
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Key Product Details
Description
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Product Description
Nutlin 3a is an MDM2 antagonist (IC50 = 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth in vivo >98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.Product Specifications
Molecular Weight
581.49
Formula
C30H30Cl2N4O4
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
CAS Number
675576-98-4
PubChem ID
11433190
InChI Key
BDUHCSBCVGXTJM-WUFINQPMSA-N
SMILES
ClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.15 | 100 | |
| Ethanol | 58.15 | 100 |
Preparing Stock Solutions
for Nutlin 3a
The following data is based on the product molecular weight 581.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.72 mL | 8.60 mL | 17.20 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.72 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vassilev In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004 PMID: 14704432
- Tovar Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc.Natl.Acad.Sci.USA. 2006 PMID: 16443686
Product Specific Notices for Nutlin 3a
For research use only
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