HLI 373
Tocris Bioscience, part of Bio-Techne | Catalog # 3503
Hdm2 inhibitor; activates p53-dependent transcription
Key Product Details
Description
Hdm2 inhibitor; activates p53-dependent transcription
Product Description
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.Product Specifications
Molecular Weight
414.33
Formula
C18H23N5O2.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
CAS Number
1782531-99-0
PubChem ID
72193867
InChI Key
WUEMKAQTAIRDOA-UHFFFAOYSA-N
SMILES
CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 37.79 | 100 | |
| DMSO | 3.78 | 10 |
Preparing Stock Solutions
for HLI 373
The following data is based on the product molecular weight 414.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.14 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009 PMID: 19037995
- Kitagaki Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 2008 PMID: 18723490
Product Specific Notices for HLI 373
For research use only
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