9 results for "Kv11.1 Small Molecules and Peptides" in Products
Kv11.1: Small Molecules and Peptides
Human ether-a-go-go related gene (HERG) encodes the pore-forming subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is ...
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
| Alternate Names: | Tikosyn,UK 68798 |
| Chemical Name: | 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane |
| Purity: | ≥98% (HPLC) |
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
| Chemical Name: | α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| Purity: | ≥98% (HPLC) |
KV11.1 (hERG) channel activator; antiarrhythmic
| Chemical Name: | N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea |
| Purity: | ≥98% (HPLC) |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
| Chemical Name: | N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker
| Alternate Names: | Hismanal |
| Chemical Name: | 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine |
| Purity: | ≥98% (HPLC) |
KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
| Chemical Name: | N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea |
| Purity: | ≥99% (HPLC) |
Kv11.1 (hERG) channel blocker
| Chemical Name: | 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride |
| Purity: | ≥97% (HPLC) |
Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic
| Chemical Name: | (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate |
| Purity: | ≥98% (HPLC) |
Calmodulin antagonist. Inhibits myosin light chain kinase
| Chemical Name: | N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride |
| Purity: | ≥98% (HPLC) |
