Ibutilide hemifumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 3908

Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic
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Key Product Details

Description

Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic

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Product Description

Ibutilide hemifumarate is a class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

Product Specifications

Molecular Weight

442.61

Formula

C20H36N2O3S.½C4H4O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate

CAS Number

122647-32-9

PubChem ID

5281065

InChI Key

PCIOHQNIRPWFMV-WXXKFALUSA-N

SMILES

CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1.O=C(/C=C/C(O)=O)O.CCCCCCCN(CC)CCCC(O)C2=CC=C(NS(C)(=O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.26 100
DMSO 44.26 100

Preparing Stock Solutions for Ibutilide hemifumarate

The following data is based on the product molecular weight 442.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.30 mL 22.59 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ibutilide hemifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ibutilide hemifumarate

For research use only

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