W-7 hydrochloride

Name: W-7 hydrochloride
Brand: Tocris Bioscience
SKU: 0369
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0369

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Citations (43)

COA / SDS

Calmodulin antagonist. Inhibits myosin light chain kinase

Key Product Details

Description:	Calmodulin antagonist. Inhibits myosin light chain kinase
Chemical Name:	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	377.33

View Full Technical Details for W-7 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for W-7 hydrochloride

W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM) and myosin light chain kinase (IC₅₀ = 51 μM). Induces shedding of platelet receptors GPVI, GPV and GPIbα.

Compound Libraries for W-7 hydrochloride

W-7 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for W-7 hydrochloride

M. Wt	377.33
Formula	C₁₆H₂₁ClN₂O₂S.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	61714-27-0
PubChem ID	124887
InChi Key	OMMOSRLIFSCDBL-UHFFFAOYSA-N
Smiles	Cl.NCCCCCCNS(=O)(=O)C1=CC=CC2=C(Cl)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for W-7 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.89	5 with gentle warming
	DMSO	37.73	100

Preparing Stock Solutions for W-7 hydrochloride

The following data is based on the product molecular weight 377.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.50 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for W-7 hydrochloride

References are publications that support the biological activity of the product.

Gardiner Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J.Thromb.Haemost. 2007 PMID: 17445093
Tanaka and Hidaka Hydrophobic regions function in calmodulin-enzyme(s) interactions. J.Biol.Chem. 1980 PMID: 6254958
Hidaka N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6945588
Itoh and Hidaka Direct interaction of calmodulin antagonists with Ca²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 1984 PMID: 6099352
Asano Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorprom. and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea J.Pharmacol.Exp.Ther. 1989 PMID: 2810127