NS 1643

Tocris Bioscience, part of Bio-Techne | Catalog # 3062

KV11.1 (hERG) channel activator; antiarrhythmic
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Key Product Details

Description

KV11.1 (hERG) channel activator; antiarrhythmic

View all Voltage-gated Potassium Channel Activators »

Product Description

NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

Product Specifications

Molecular Weight

380.24

Formula

C15H10F6N2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

CAS Number

448895-37-2

PubChem ID

10177784

InChI Key

NJFVQMRYJZHGME-UHFFFAOYSA-N

SMILES

OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.51 25
Ethanol 38.02 100

Preparing Stock Solutions for NS 1643

The following data is based on the product molecular weight 380.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.30 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 1643

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 1643

For research use only

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