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gp130 Products

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.

61 results for "gp130" in Products

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gp130 Products

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.

61 results for "gp130" in Products

gp130 modulator; activates JAK/STAT signaling

Simple Plex Cartridge Kit containing gp130 for use with Human CCS/Plasma/Serum. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.

Catalog #: BAF468
WB, Flow
Flow, CyTOF-ready, ICC
Flow, CyTOF-ready, Neut
BA

Biotinylated

Catalog #: FAB4681G
Flow
Catalog #: 5029-RG
BA
Catalog #: FAB4681U
Flow
WB, Flow, CyTOF-ready
WB

gp130 agonist; brain penetrant and neuroprotectant

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