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gp130: Small Molecules and Peptides
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
3 results for "gp130 Small Molecules and Peptides" in Products
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gp130: Small Molecules and Peptides
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
3 results for "gp130 Small Molecules and Peptides" in Products
gp130 agonist; brain penetrant and neuroprotectant
| Chemical Name : | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine |
| Purity : | ≥98% (HPLC) |
gp130 modulator; activates JAK/STAT signaling
| Chemical Name : | N-(4-Bromophenyl)-4-phenyl-2-thiazolamine |
| Purity : | ≥98% (HPLC) |
gp130 inhibitor; blocks cytokine-triggered gp130 signaling
| Chemical Name : | 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride |
| Purity : | ≥98% (HPLC) |
