UCLA GP130 2

Name: UCLA GP130 2
Brand: Tocris Bioscience
SKU: 6583

Tocris Bioscience a Bio-Techne Brand

Catalog # 6583

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Key Product Details

Description:	gp130 agonist; brain penetrant and neuroprotectant
Chemical Name:	N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Purity:	≥98% (HPLC)
Molecular Weight:	270.32

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Biological Activity for UCLA GP130 2

UCLA GP130 2 is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.

Compound Libraries for UCLA GP130 2

UCLA GP130 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UCLA GP130 2

M. Wt	270.32
Formula	C₁₅H₁₁FN₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	339303-87-6
PubChem ID	1284592
InChi Key	HXVFUSRCVKYALB-UHFFFAOYSA-N
Smiles	FC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UCLA GP130 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.03	100
	ethanol	27.03	100

Preparing Stock Solutions for UCLA GP130 2

The following data is based on the product molecular weight 270.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	36.99 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for UCLA GP130 2

References are publications that support the biological activity of the product.

Alam A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 2018 PMID: 29161500

Citations for UCLA GP130 2

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