SC 144 hydrochloride

Name: SC 144 hydrochloride
Brand: Tocris Bioscience
SKU: 4963

Tocris Bioscience, part of Bio-Techne | Catalog # 4963

Citations (8)

COA / SDS

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Key Product Details

Description:	gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Chemical Name:	2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	358.76

View Full Technical Details for SC 144 hydrochloride

Technical Data
Citations

Biological Activity for SC 144 hydrochloride

SC 144 hydrochloride is an inhibitor of gp130 (IC₅₀ = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Compound Libraries for SC 144 hydrochloride

SC 144 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SC 144 hydrochloride

M. Wt	358.76
Formula	C₁₆H₁₁FN₆O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	917497-70-2
PubChem ID	66921431
InChi Key	LKFGGXYXFIICED-UHFFFAOYSA-N
Smiles	O=C(C4=CN=CC=N4)NNC1=NC(C=C(F)C=C3)=C3N2C1=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 144 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.23	100

Preparing Stock Solutions for SC 144 hydrochloride

The following data is based on the product molecular weight 358.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.94 mL	27.87 mL
5 mM	0.56 mL	2.79 mL	5.57 mL
10 mM	0.28 mL	1.39 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for SC 144 hydrochloride

References are publications that support the biological activity of the product.

Xu Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 2013 PMID: 23536726