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16 results for "Estrogen and Related Receptor Agonists Small Molecules and Peptides" in Products

Estrogen and Related Receptor Agonists: Small Molecules and Peptides

The GPER (G protein-coupled estrogen receptor, GPR30) is a membrane protein that binds estrogen leading to estrogen-mediated adenylyl cyclase stimulation. The receptor is widely distributed in neural, breast, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissues. The GPER binds estradiol with high affinity, but has lower affinity for the other estrogens, estrone and estriol. The receptor acts independently of ERα and ERβ and triggers ER-dependent EGFR action.

Potent pan-ERR agonist

Chemical Name: (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
Purity: ≥98% (HPLC)
Potent pan-ERR agonist

Estrogen receptor antagonist

Alternate Names: Fulvestrant
Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
Purity: ≥98% (HPLC)
Estrogen receptor antagonist

Endogenous ER agonist

Alternate Names: 17 β-Estradiol
Chemical Name: (17β)-Estra-1,3,5(10)-triene-3,17-diol
Purity: ≥98% (HPLC)
Endogenous ER agonist

Agonist selective for estrogen-related receptors ERRβ and ERRγ

Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Purity: ≥98% (HPLC)
Agonist selective for estrogen-related receptors ERRβ and ERRγ

Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes

Chemical Name: 2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
Purity: ≥98% (HPLC)
Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes

Subtype-selective ERα agonist

Chemical Name: 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Purity: ≥98% (HPLC)
Subtype-selective ERα agonist

Highly potent ERβ agonist

Alternate Names: Diarylpropionitrile
Chemical Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity: ≥98% (HPLC)
Highly potent ERβ agonist

Estrogen receptor partial agonist/antagonist

Chemical Name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Purity: ≥98% (HPLC)
Estrogen receptor partial agonist/antagonist

Endogenous estrogen receptor agonist

Chemical Name: (17α)-Estra-1,3,5(10)-triene-3,17-diol
Purity: ≥97% (HPLC)
Endogenous estrogen receptor agonist

Potent and selective GPER agonist

Chemical Name: (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone
Purity: ≥98% (HPLC)
Potent and selective GPER agonist

Non-selective PI 3-kinase inhibitor

Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Non-selective PI 3-kinase inhibitor

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Chemical Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Potent G protein-coupled estrogen receptor (GPER) agonist

Chemical Name: N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
Purity: ≥98% (HPLC)
Potent G protein-coupled estrogen receptor (GPER) agonist

Potent and selective ERβ agonist; neuroprotective

Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Purity: ≥98% (HPLC)
Potent and selective ERβ agonist; neuroprotective

Potent ERβ agonist

Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥98% (HPLC)
Potent ERβ agonist

LXR agonist; also ER partial agonist

Alternate Names: 27 OHC,27 HC
Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Purity: ≥95% (HPLC)
LXR agonist; also ER partial agonist
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