Tamoxifen citrate

Name: Tamoxifen citrate
Brand: Tocris Bioscience
SKU: 0999
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0999

Citations (11)

(1)

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Key Product Details

Description:	Estrogen receptor partial agonist/antagonist
Chemical Name:	(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Purity:	≥99% (HPLC)
Molecular Weight:	563.65

View Full Technical Details for Tamoxifen citrate

Biological Activity for Tamoxifen citrate

Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat. No. 6432) is also available.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for Tamoxifen citrate

Tamoxifen citrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tamoxifen citrate

M. Wt	563.65
Formula	C₂₆H₂₉NO.C₆H₈O₇
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	54965-24-1
PubChem ID	2733525
InChi Key	FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Smiles	CC/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/C1=CC=C(OCCN(C)C)C=C1.O=C(O)CC(O)(C(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tamoxifen citrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.82	5 with gentle warming
	DMSO	56.37	100

Preparing Stock Solutions for Tamoxifen citrate

The following data is based on the product molecular weight 563.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for Tamoxifen citrate

References are publications that support the biological activity of the product.

Todorova Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011 PMID: 20383709
Thomas Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005 PMID: 15539556
Mehta Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 2003 PMID: 12624540
Paul Both the immunosuppressant SR31747 and the antioestrogen tamox. bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 1998 PMID: 9618436
Wakeling Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 1984 PMID: 6538611

Citations for Tamoxifen citrate (11)

Showing 1 - 10 of 11 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Tamoxifen citrate include:

Ronghe et al. (2016) Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells. Oncotarget. 7:51747
PMID: 27351134
Bertrand et al. (2015) HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. Acta Pharm Sin B. 6:894
PMID: 26441850
Sheng et al. (2015) DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy. J Urol. 5:330
PMID: 26579463
Nicholson et al. (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. PLoS One. 193:722
PMID: 25167991
Todd et al. (2015) Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone. FEMS Immunol Med Microbiol. 10:e0140260
PMID: 26451596
Gutierrez et al. (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem. 289:33568
PMID: 25301941
Gibbs et al. (2014) Role of GPR30 in mediating OE effects on acetylcholine release in the hippocampus. Horm Behav. 66:339
PMID: 24928571
Mansouri-Attia et al. (2014) Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 91:100
PMID: 25165122
Antoon et al. (2012) Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation. Cancer Biol Ther. 13:1026
PMID: 22825349
Tremere et al. (2009) OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression. J Neurosci. 29:5949
PMID: 19420261
Wieland et al. (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Neurosci. 47:296
PMID: 16831218

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Blocks effects of estradoil

Name: Ourlad Alzeus Tantengco

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Endocervical Epithelial Cells

Tamoxifen (1 ug/mL) was used to block the effects of estradiol in endocervical epithelial cells on intermediate filament (cytokeratin 18 and vimentin) expression.

PMID: 33152143 Reference

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Product Documents for Tamoxifen citrate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Tamoxifen citrate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov