Tamoxifen citrate
Tocris Bioscience, part of Bio-Techne | Catalog # 0999
Estrogen receptor partial agonist/antagonist
Key Product Details
Description
Estrogen receptor partial agonist/antagonist
Product Description
Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat. No. 6432) is also available.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
563.65
Formula
C26H29NO.C6H8O7
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
CAS Number
54965-24-1
PubChem ID
2733525
InChI Key
FQZYTYWMLGAPFJ-OQKDUQJOSA-N
SMILES
CC/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/C1=CC=C(OCCN(C)C)C=C1.O=C(O)CC(O)(C(O)=O)CC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.37 | 100 | |
| Ethanol | 2.82 | 5 with gentle warming |
Preparing Stock Solutions
for Tamoxifen citrate
The following data is based on the product molecular weight 563.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.87 mL | 17.74 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Todorova Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011 PMID: 20383709
- Paul Both the immunosuppressant SR31747 and the antioestrogen tamox. bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 1998 PMID: 9618436
- Mehta Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 2003 PMID: 12624540
- Thomas Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005 PMID: 15539556
- Wakeling Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 1984 PMID: 6538611
Product Specific Notices for Tamoxifen citrate
For research use only
⚠ WARNING: This product can expose you to chemicals including Tamoxifen citrate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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