T 112
Tocris Bioscience, part of Bio-Techne | Catalog # 7690
Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
Key Product Details
Description
Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
Product Description
T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.Licensing Information
Sold under license from Orizuru TherapeuticsProduct Specifications
Molecular Weight
489.37
Formula
C25H21BrN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
CAS Number
2376876-87-6
PubChem ID
151597503
InChI Key
QJTVIYLRDQROJD-UHFFFAOYSA-N
SMILES
BrC1=CC=C(C2=NC3=CC=C(N4CC5=CC(N6CCOCC6)=CC=C5C4=O)C=C3N2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.89 | 10 |
Preparing Stock Solutions
for T 112
The following data is based on the product molecular weight 489.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.43 mL | 102.17 mL | 204.34 mL |
| 0.5 mM | 4.09 mL | 20.43 mL | 40.87 mL |
| 1 mM | 2.04 mL | 10.22 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miki ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 2021 PMID: 34155205
Product Specific Notices for T 112
For research use only
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