Genistein

Name: Genistein
Brand: Tocris Bioscience
SKU: 1110

Catalog # 1110

Citations (10)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	EGFR kinase inhibitor. Also estrogen and PPARγ ligand
Chemical Name:	5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.24

View Full Technical Details for Genistein

Complete Your Research

Biological Activity

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ₄₂ and amylin₃₇ (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Compound Libraries

Genistein is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	270.24
Formula	C₁₅H₁₀O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	446-72-0
PubChem ID	5280961
InChi Key	TZBJGXHYKVUXJN-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Pierzynowska Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients. Metab.Brain Dis. 2019 PMID: 30850940
Ren Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides. ACS.Chem.Neurosci. 2018 PMID: 29432676
Dang Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein. J.Biol.Chem. 2003 PMID: 12421816
Migita Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors. J.Immunol. 1994 PMID: 7523495
Linassier Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem.Pharmacol. 1990 PMID: 2153378
Akiyama Genistein, a specific inhibitor of tyrosine-specific protein kinases. J.Biol.Chem. 1987 PMID: 3106339

Citations for Genistein (10)

Showing 1 - 10 of 10 citations Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Genistein include:

Kim et al. (2018) Estrogen modulates serotonin effects on vasoconstriction through Src inhibition. Exp Mol Med. 50:167
PMID: 30559345
Olianas et al. (2016) The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABA_B receptors European Journal of Pharmacology. 794:135
PMID: 27876620
Liu et al. (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal. 8:ra71
PMID: 26198357
Accardi et al. (2015) α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells. J Neurosci. 35:9676
PMID: 26134650
Mansouri-Attia et al. (2014) Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 91:100
PMID: 25165122
Bigford et al. (2012) 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-MthD.-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 287:11049
PMID: 22291020
Li et al. (2011) Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS One. 6:e26065
PMID: 22022509
Melis et al. (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors. J Neurosci. 28:13985
PMID: 19091987
Rojas et al. (2007) Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel. Biochim Biophys Acta. 1768:2030
PMID: 17585871
Alao et al. (2006) Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Neurotox Res. 5:40
PMID: 17018141

There are no citations that match your criteria.