Quercetin

Name: Quercetin
Brand: Tocris Bioscience
SKU: 1125
Price: 89 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1125

Citations (3)

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Key Product Details

Description:	Non-selective PI 3-kinase inhibitor
Chemical Name:	2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	302.24

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Biological Activity for Quercetin

Quercetin is an antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A₂, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca²⁺ and K⁺ channels and behaves as an agonist at estrogen (GPER) receptors. Blocks cellular entry by influenza A virus via an interaction with hemaglutinin. Inhibits SARS-CoV 3CL^pro (IC₅₀ = 73 μM).

Technical Data for Quercetin

M. Wt	302.24
Formula	C₁₅H₁₀O₇
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	117-39-5
PubChem ID	5280343
InChi Key	REFJWTPEDVJJIY-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Quercetin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Quercetin

The following data is based on the product molecular weight 302.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.54 mL	33.09 mL
5 mM	0.66 mL	3.31 mL	6.62 mL
10 mM	0.33 mL	1.65 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for Quercetin

References are publications that support the biological activity of the product.

Wu Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses 2015 PMID: 26712783
Nguyen Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol.Lett. 2012 PMID: 22350287
Cermak The flavonol quercetin activates basolateral K⁺ channels in rat distal colon epithelium. Br.J.Pharmacol. 2002 PMID: 11877325
Saponara Quercetin as a novel activator of L-type Ca²⁺ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 2002 PMID: 11934824
Wei Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 1994 PMID: 8069862
Levy Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 1984 PMID: 6091650
Graziani The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 1983 PMID: 6311542

Citations for Quercetin (3)

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Citations are publications that use Bio-Techne products. Selected citations for Quercetin include:

Rees et al. (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Neurochem Int. 12:109
PMID: 26656090
Yao et al. (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun. 4:42
PMID: 27117475
Filone et al. (2014) The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog. 10:e1003904
PMID: 24516381

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