AC 186

Tocris Bioscience, part of Bio-Techne | Catalog # 5053

Potent and selective ERβ agonist; neuroprotective
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Key Product Details

Description

Potent and selective ERβ agonist; neuroprotective

View all Estrogen and Related Receptor Agonists »

Product Description

AC 186 is a potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

Product Specifications

Molecular Weight

306.32

Formula

C18H17F3O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

CAS Number

1421854-16-1

PubChem ID

71245042

InChI Key

HSMUKSLNDJOZQG-UHFFFAOYSA-N

SMILES

FC1(F)CCC(C2=C(F)C=CC=C2)(C3=CC=C(O)C=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.63 100

Preparing Stock Solutions for AC 186

The following data is based on the product molecular weight 306.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.65 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Documents for AC 186

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AC 186

For research use only

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