AC 186

Name: AC 186
Brand: Tocris Bioscience
SKU: 5053

Tocris Bioscience a Bio-Techne Brand

Catalog # 5053

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Key Product Details

Description:	Potent and selective ERβ agonist; neuroprotective
Chemical Name:	4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Purity:	≥99% (HPLC)
Molecular Weight:	306.32

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Biological Activity for AC 186

AC 186 is a potent and selective ERβ agonist (EC₅₀ values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

Compound Libraries for AC 186

AC 186 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 186

M. Wt	306.32
Formula	C₁₈H₁₇F₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1421854-16-1
PubChem ID	71245042
InChi Key	HSMUKSLNDJOZQG-UHFFFAOYSA-N
Smiles	FC1(F)CCC(C2=C(F)C=CC=C2)(C3=CC=C(O)C=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 186

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.63	100

Preparing Stock Solutions for AC 186

The following data is based on the product molecular weight 306.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.65 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for AC 186

References are publications that support the biological activity of the product.

George Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 2013 PMID: 24020966
McFarland AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 2013 PMID: 23898966

Citations for AC 186

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