Key Product Details
Description: | Estrogen receptor antagonist |
Alternative Names: | Fulvestrant |
Chemical Name: | 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 606.77 |
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Citations for ICI 182,780 (284)
Citations are publications that use Bio-Techne products. Selected citations for ICI 182,780 include:
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Demas et al.
(2019)
Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.
Front Oncol.
9:686
PMID: 31428575 -
Bloomfield and Louie
(2019)
Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα.
Sci Rep.
9:12135
PMID: 31431634 -
Rincó n-Rodriguez et al.
(2019)
F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
Int J Mol Sci.
20
PMID: 31394756 -
Hosford et al.
(2019)
Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
Mol Oncol.
13:1778
PMID: 31180176 -
Kasonga et al.
(2019)
Data on UPLC/MS method validation for the biodegradation of pharmaceuticals and intermediates by a fungal consortium and on T47DK-Bluc reporter gene assay to assess the reduction of their estrogenic activity.
Data Brief.
25:104336
PMID: 31453302 -
Cortes et al.
(2019)
TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Oncogene.
38:2910
PMID: 30575816 -
Cortes et al.
(2019)
TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
EMBO Rep.
20
PMID: 30538116 -
Cortes et al.
(2019)
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
EMBO Rep.
20
PMID: 30538117 -
Gibson et al.
(2018)
The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
Endocr Relat Cancer.
25:381
PMID: 29371332 -
Jallow et al.
(2018)
17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes.
J Endocr Soc.
2:293
PMID: 29594259 -
Kaymak et al.
(2018)
Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance.
Oncotarget.
9:28666
PMID: 29983888 -
Du et al.
(2018)
Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
Breast Cancer Res.
20:106
PMID: 30180878 -
Ulhaq and Kishida
(2018)
Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae.
Front Endocrinol (Lausanne).
9:230
PMID: 29867763 -
Rabaglino et al.
(2018)
A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780.
Physiol Rep.
6:e13871
PMID: 30221477 -
Li et al.
(2018)
Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
Endocrinology.
159:285
PMID: 29029116 -
Simões et al.
(2018)
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.
Ther Adv Med Oncol.
10:1758835918766180
PMID: 29636827 -
Stender
(2017)
Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells.
Mol Cell.
65(6):1122
PMID: 28306507 -
Zhu
(2017)
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.
PLoS One.
12(2):e0171390
PMID: 28152041 -
Lou et al.
(2017)
OE Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1.
Int J Biol Sci.
13:434
PMID: 28529452 -
Lu et al.
(2017)
Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β.
Oncotarget.
8:38767
PMID: 28404976 -
Panza et al.
(2017)
E2 via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
Tumour Biol.
39:1010428317701640
PMID: 28459202 -
Wong et al.
(2017)
Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta.
Br J Pharmacol.
174:718
PMID: 28138957 -
Maselli et al.
(2016)
Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus.
Front Vet Sci.
7:3
PMID: 26759713 -
Mao et al.
(2016)
Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI
Scientific Reports.
6:34753
PMID: 27713477 -
Bains and Roberts
(2016)
Estrogen protects against DA neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
Neurosci Lett.
610:79
PMID: 26520464 -
Pastore et al.
(2016)
Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
Biol Reprod.
94:139
PMID: 27170438 -
Gupta et al.
(2016)
NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
Oncogene.
35:5860
PMID: 27109102 -
Peretz et al.
(2016)
Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.
Am J Physiol Lung Cell Mol Physiol.
310:L415
PMID: 26684252 -
Diep et al.
(2016)
Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes.
Steroids.
114:48
PMID: 27641443 -
Ciucci et al.
(2016)
Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers.
Oncotarget.
7:8155
PMID: 26797759 -
Xu et al.
(2015)
A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
Redox Biol.
6:446
PMID: 26402163 -
Tomita et al.
(2015)
A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.
Nat Commun.
6:6966
PMID: 25923108 -
Tozzi et al.
(2015)
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Front Cell Neurosci.
9:192
PMID: 26074768 -
Castro et al.
(2015)
Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: OE regulation.
Biol Res.
48:56
PMID: 26453052 -
Albanito et al.
(2015)
Effects of Atrazine on Estrogen Receptor α- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.
Environ Health Perspect.
123:493
PMID: 25616260 -
Kastrati et al.
(2015)
PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Oncogene.
34:2309
PMID: 24954507 -
Harvey et al.
(2015)
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
Reprod Toxicol.
51:72
PMID: 25549949 -
Kim et al.
(2015)
Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells.
Reproduction.
149:453
PMID: 25687410 -
Simões et al.
(2015)
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Cell Cycle.
12:1968
PMID: 26387946 -
Wang et al.
(2015)
Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH3 cells.
Cancer Cell Int.
7:8498
PMID: 25674214 -
Zhou et al.
(2015)
Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.
Endocrinology.
14:540
PMID: 25663821 -
Hole et al.
(2015)
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulves. treatment and cross-resistance between letr. and exeme.
BMC Cancer.
46:1481
PMID: 25625755 -
Larsen et al.
(2015)
Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamox. resistant breast cancer.
Aging Cell.
15:239
PMID: 25885472 -
Xiong et al.
(2015)
Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.
Breast Cancer Res Treat.
14:867
PMID: 26111662 -
Bean et al.
(2015)
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Oncotarget.
149:69
PMID: 25491778 -
Luzhna et al.
(2015)
Altered radiation responses of breast cancer cells resistant to hormonal therapy.
Mol Cell Biol.
6:1678
PMID: 25682200 -
Hu et al.
(2015)
NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.
Oncogenesis.
35:379
PMID: 25368386 -
Miyoshi et al.
(2015)
Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulves. action and breast cancer prognosis.
Biol Sex Differ.
4:e172
PMID: 26479444 -
Shappell et al.
(2015)
The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture.
Cancer Lett.
2:30
PMID: 26664959 -
Myers et al.
(2015)
Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products.
BMC Cancer.
25:271
PMID: 24849798 -
Segovia-Mendoza et al.
(2015)
Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study.
J Biol Chem.
15:21
PMID: 25622528 -
Wardell et al.
(2015)
Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
Endocr Relat Cancer.
22:713
PMID: 26162914 -
Wu et al.
(2015)
Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.
Atherosclerosis.
240:453
PMID: 25898000 -
Fan et al.
(2014)
A molecular model for the mechanism of acquired tamox. resistance in breast cancer.
Eur J Cancer.
50:2866
PMID: 25204804 -
Gottardo et al.
(2014)
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
PLoS One.
9:e111548
PMID: 25360890 -
Alao et al.
(2014)
Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
BMC Cancer.
14:853
PMID: 25409876 -
Fan et al.
(2014)
Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.
Eur J Cancer.
50:457
PMID: 24183378 -
Haagenson et al.
(2014)
Functional analysis of MKP-1 and MKP-2 in breast cancer tamox. sensitivity.
Oncotarget.
5:1101
PMID: 24658355 -
Oróstica et al.
(2014)
OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
Reproduction.
148:285
PMID: 25038866 -
Hill and Muldrew
(2014)
Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
Clin Exp Pharmacol Physiol.
41:430
PMID: 24684418 -
Liang et al.
(2014)
Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4.
J Biol Chem.
289:23534
PMID: 25012664 -
Colciago et al.
(2014)
In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells.
Biomed Res Int.
2014:801473
PMID: 24877132 -
Giretti et al.
(2014)
Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.
Front Endocrinol (Lausanne).
5:80
PMID: 24904530 -
Adomas et al.
(2014)
Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.
BMC Cancer.
14:278
PMID: 24758297 -
Yi et al.
(2014)
Anti-tumor efficacy of fulves. in estrogen receptor positive gastric cancer.
Sci Rep.
4:7592
PMID: 25534230 -
Choi et al.
(2014)
Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Cell Rep.
221:39
PMID: 24443716 -
Seo et al.
(2014)
Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs.
Breast Cancer Res.
90:99
PMID: 24695626 -
Speroni et al.
(2014)
Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.
PLoS One.
20:42
PMID: 23675751 -
Nag and Mokha
(2014)
Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
Am J Physiol Regul Integr Comp Physiol.
267:122
PMID: 24613724 -
Cook and Clarke
(2014)
Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer.
Steroids.
1
PMID: 26005699 -
Jafaar et al.
(2014)
β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression.
Int J Oncol.
44:1365
PMID: 24534923 -
Yonova et al.
(2014)
Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents.
J Org Chem.
79:1947
PMID: 24564865 -
Teng et al.
(2013)
Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
Toxicol Sci.
131:71
PMID: 23052036 -
Johansson et al.
(2013)
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Nat Commun.
4:2175
PMID: 23868472 -
Greaves et al.
(2013)
ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.
Hum Reprod.
28:2490
PMID: 23756706 -
Morandi et al.
(2013)
GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
Cancer Res.
73:3783
PMID: 23650283 -
Kim et al.
(2013)
The effect of estrogen compounds on human embryoid bodies.
Proc Natl Acad Sci U S A.
20:661
PMID: 23184660 -
Aida-Yasuoka et al.
(2013)
OE promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
J Neurosci.
15:R10
PMID: 23305385 -
Aupperlee et al.
(2013)
Amphiregulin mediates progesterone-induced mammary ductal development during puberty.
J Neurosci.
15:R44
PMID: 23705924 -
Sievers et al.
(2013)
Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β.
Proc Natl Acad Sci U S A.
132:359
PMID: 22989670 -
Ruiz et al.
(2013)
Induction of hepatic multidrug resistance-associated protein 3 by ethynylOE is independent of cholestasis and mediated by estrogen receptor.
Proc Natl Acad Sci U S A.
41:275
PMID: 23077105 -
Zhang et al.
(2013)
Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells.
Environ Health Perspect.
139:351
PMID: 23686416 -
Smith et al.
(2013)
The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-OE.
Am J Physiol Endocrinol Metab.
305:E632
PMID: 23820624 -
Giordano et al.
(2013)
Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression.
Free Radic Biol Med.
58:98
PMID: 23376469 -
Spink et al.
(2013)
Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells.
Mol Carcinog.
52:544
PMID: 22388733 -
Varea et al.
(2013)
OOE signalling through the Akt-mTORC1-S6K1.
Biochim Biophys Acta.
1833:1052
PMID: 23295457 -
Wen et al.
(2012)
Modulation of ovine SBD-1 expression by 17beta-OE in ovine oviduct epithelial cells.
BMC Vet Res.
8:143
PMID: 22920556 -
Bobustuc et al.
(2012)
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
Mol Med.
18:913
PMID: 22549111 -
Mahmoodzadeh et al.
(2012)
17β-OE-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.
Cardiovasc Res.
96:411
PMID: 22962310 -
Antoon et al.
(2012)
Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
Cancer Biol Ther.
13:1026
PMID: 22825349 -
Babu et al.
(2012)
Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
J Nutr.
142:724
PMID: 22399524 -
Wang and Kuehl-Kovarik
(2012)
OE directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
Brain Res.
1436:81
PMID: 22209345 -
Ropero et al.
(2012)
Insotropic effect of the non-steroidal compound STX in pancreatic β-cells.
PLoS One.
7:e34650
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Cao et al.
(2012)
Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
J Pain.
13:685
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Youn et al.
(2012)
Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.
Clin Sci (Lond).
123:509
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Rodriguez-Ubreva et al.
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Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
Nucleic Acids Res.
40:1954
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González-Arenas et al.
(2012)
OE increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
Biochim Biophys Acta.
1823:379
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Collins-Burow et al.
(2012)
Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
J Steroid Biochem Mol Biol.
132:186
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Peretz et al.
(2012)
Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway.
Biol Reprod.
87:63
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Leal et al.
(2012)
p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.
PLoS One.
7:e49817
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Shim and Lee
(2012)
Estrogen receptor is activated by korean red ginseng in vitro but not in vivo.
J Ginseng Res.
36:169
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Niu et al.
(2012)
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
J Cereb Blood Flow Metab.
153:2283
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Vinnedge et al.
(2012)
The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
Neuroscience.
7:e46985
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Guido et al.
(2012)
Estrogen receptor β (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene.
Int J Clin Exp Pathol.
11:2911
PMID: 22810004 -
Zuloaga et al.
(2012)
Estrogen receptor β dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries.
Exp Neurol.
77:835
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Cook et al.
(2012)
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Int J Mol Sci.
72:3337
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Lee et al.
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Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells.
Endocrinology.
12:260
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Park et al.
(2012)
Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia.
Proc Natl Acad Sci U S A.
20:183
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Richardson et al.
(2012)
Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
Endocrinology.
7:e34600
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Brion et al.
(2012)
Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.
PLoS One.
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Zhang et al.
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Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β.
J Cell Physiol.
227:146
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Tyagi et al.
(2011)
Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect.
PLoS One.
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He et al.
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Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells.
Acta Biochim Biophys Sin (Shanghai).
43:118
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Zheng et al.
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17β-OE enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.
PLoS One.
6:e22439
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Burns et al.
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Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.
J Biol Chem.
286:12640
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Yu et al.
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mTOR controls ovarian follicle growth by regulating granulosa cell proliferation.
PLoS One.
6:e21415
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Ivanova et al.
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Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
FASEB J.
25:1402
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Baquié et al.
(2011)
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {β}-cells against stress-induced apoptosis.
FEMS Immunol Med Microbiol.
20:2823
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Hsu et al.
(2011)
JNK suppression is essential for 17β-OE inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
J Vet Sci.
18:61
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Ahn et al.
(2011)
Expression and regulation of Enpp2 in rat uterus during the estrous cycle.
Toxicol Sci.
12:379
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Corcoran et al.
(2011)
The effect of 17β-OE on cholesterol content in human macrophages is influenced by the lipoprotein milieu.
Clin Cancer Res.
47:109
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Thangavel et al.
(2011)
Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.
Endocr Relat Cancer.
18:333
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Liu et al.
(2011)
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal mor. antinociception.
J Neurosci.
31:11836
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Richardson et al.
(2011)
Estrogen protection in Friedreich's ataxia skin fibroblasts.
Endocrinology.
152:2742
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Shanle et al.
(2011)
Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.
Biochem Pharmacol.
82:1940
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Lappano et al.
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The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes.
PLoS One.
6:e16631
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Sherrill et al.
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Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation.
Biol Reprod.
83:488
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Pradhan et al.
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Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.
J Biol Chem.
285:31100
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Sunters et al.
(2010)
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
J Biol Chem.
285:8743
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Madeo et al.
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c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.
Oncogene.
29:978
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Customer Reviews for ICI 182,780 (1)
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Species: HumanAssay Type: In VitroCell Line/Tissue: Human Primary Mammary Epithelial CellsThis product was dissolved in ethanol and delivered to human primary mammary epithelial cells in vitro.
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