Key Product Details
Description: | Potent and selective GPER agonist |
Chemical Name: | (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 412.28 |
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Citations for G-1 (19)
Citations are publications that use Bio-Techne products. Selected citations for G-1 include:
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Loiola et al.
(2019)
Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1.
Front Endocrinol (Lausanne).
10:420
PMID: 31297095 -
Cortes et al.
(2019)
TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Oncogene.
38:2910
PMID: 30575816 -
Meseke et al.
(2018)
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Eneuro.
5
PMID: 30406178 -
Caballero et al.
(2017)
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.
Sci Rep.
7:40981
PMID: 28112187 -
Huang et al.
(2016)
GPR30 decreases with vascular aging and promotes vascular smooth muscle cells maintaining differentiated phenotype and suppressing migration via activation of ERK1/2.
Onco Targets Ther.
9:3415
PMID: 27354813 -
Chimento et al.
(2015)
GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo.
Cell Death Dis.
6:19190
PMID: 26131713 -
Santolla et al.
(2015)
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
Sci Rep.
6:e1834
PMID: 26225773 -
Villa et al.
(2015)
Estrogen accelerates the resolution of inflammation in macrophagic cells.
Breast Cancer Res.
5:15224
PMID: 26477569 -
Yuan et al.
(2015)
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamox. resistance through cancer-associated fibroblast-derived fibronectin and
Dis Model Mech.
17:69
PMID: 25990368 -
Lappano et al.
(2015)
A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models.
Cell Death Dis.
8:1237
PMID: 26183213 -
Mazzuca et al.
(2015)
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
J Pharmacol Exp Ther.
352:291
PMID: 25472954 -
An et al.
(2014)
Estrogen rapidly enhances incisional pain of ovariectomized rats primarily through the G protein-coupled estrogen receptor.
Brain Behav.
15:10479
PMID: 24921706 -
Anchan et al.
(2014)
GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice.
Am J Physiol Renal Physiol.
4:51
PMID: 24653954 -
Nag and Mokha
(2014)
Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
Oncotarget.
267:122
PMID: 24613724 -
Sandner et al.
(2014)
Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.
Andrology.
2:695
PMID: 25052196 -
Francesco et al.
(2014)
GPER mediates activation of HIF1α/VEGF signaling by estrogens.
Cancer Res.
74:4053
PMID: 24894716 -
Engelstoft et al.
(2013)
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
Mol Metab.
2:376
PMID: 24327954 -
Chimento et al.
(2013)
Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells.
Int J Mol Sci.
4:e747
PMID: 23907461 -
Duncan et al.
(2012)
2-MethoxyOE inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.
Proc Natl Acad Sci U S A.
109:21034
PMID: 23213242
There are no citations that match your criteria.