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22 results for "Compounds for Stem Cell Differentiation" in Products

Compounds for Stem Cell Differentiation

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

GMP Version Available: TB6053-GMP
GMP
Alternate Names:
LDN 193189 2HCl
Chemical Name:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity:
≥98%
Application of LDN 193189 in motor neurons differentiated from iPSCs
(2)

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names:
Compound C,BML-275
Chemical Name:
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity:
≥98%
Potent AMPK inhibitor; also BMP type I receptor inhibitor

Selective JNK inhibitor

Chemical Name:
Anthra[1-9-cd]pyrazol-6(2H)-one
Purity:
≥98%
Selective JNK inhibitor

Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.

Alternate Names:
SIK inhibitor 1
Chemical Name:
1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
Purity:
≥98%
Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.

Selective ALK2 inhibitor

Chemical Name:
4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Purity:
≥98%
Selective ALK2 inhibitor

FGFR1 and -3 inhibitor

Chemical Name:
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity:
≥98%
FGFR1 and -3 inhibitor

5-HT reuptake inhibitor

Chemical Name:
N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Purity:
≥98%
5-HT reuptake inhibitor

CK1 inhibitor

Chemical Name:
N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity:
≥99%
CK1 inhibitor

Histone deacetylase inhibitor

Chemical Name:
Butanoic acid sodium salt
Histone deacetylase inhibitor

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Chemical Name:
N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity:
≥98%
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

PDE inhibitor (non-selective)

Chemical Name:
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Purity:
≥98%
PDE inhibitor (non-selective)

Potent, reversible EGFR tyrosine kinase inhibitor

Chemical Name:
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
Purity:
≥98%
Potent, reversible EGFR tyrosine kinase inhibitor

Potent inhibitor of Wnt/β-catenin signaling

Chemical Name:
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity:
≥98%
Potent inhibitor of Wnt/β-catenin signaling

Highly potent and selective GSK-3 inhibitor

Chemical Name:
N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
Purity:
≥98%
Highly potent and selective GSK-3 inhibitor

DNA methyltransferase inhibitor

Chemical Name:
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Purity:
≥98%
DNA methyltransferase inhibitor

SCD-1 inhibitor

Alternate Names:
NSC 14613
Chemical Name:
4-Pyridinecarboxylic acid 2-phenylhydrazide
Purity:
≥99%
SCD-1 inhibitor

Potent and selective Foxo1 inhibitor; orally bioavailable

Chemical Name:
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Purity:
≥98%
Potent and selective Foxo1 inhibitor; orally bioavailable

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

Alternate Names:
JAK inhibitor I
Chemical Name:
2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one
Purity:
≥98%
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

HIF α-subunit inhibitor

Chemical Name:
2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
Purity:
≥98%
HIF α-subunit inhibitor

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Chemical Name:
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Purity:
≥97%
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells

Alternate Names:
RG-4733
Chemical Name:
2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide
Purity:
≥98%
Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells

Chemical Name:
N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide
Purity:
≥98%
Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
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