FM19G11

Name: FM19G11
Brand: Tocris Bioscience
SKU: 6653
Rating: 4 (1 reviews)

Catalog # 6653 | Tocris Bioscience a Bio-Techne Brand

(1)

COA / SDS

HIF α-subunit inhibitor

Key Product Details

Description:	HIF α-subunit inhibitor
Chemical Name:	2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
Purity:	≥98% (HPLC)
Molecular Weight:	463.4

View Full Technical Details for FM19G11

Biological Activity for FM19G11

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC₅₀ = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O⁶-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Compound Libraries for FM19G11

FM19G11 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for FM19G11

M. Wt	463.4
Formula	C₂₃H₁₇N₃O₈
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	329932-55-0
PubChem ID	1730746
InChi Key	XVUOIWIIQVGWAJ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C(COC(C2=CC=CC(NC(C3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)=O)=C2)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FM19G11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.34	100

Preparing Stock Solutions for FM19G11

The following data is based on the product molecular weight 463.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for FM19G11

References are publications that support the biological activity of the product.

Alastrue-Agudo FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 2018 PMID: 29315225
You FM19G11 inhibits O⁶-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 PMID: 29761922
Moreno-Manzano FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 2010 PMID: 19897487

Citations for FM19G11

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Customer Reviews for FM19G11 (1)

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good product, satisfied

Name: Kishor Pant

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Hepg2, Huh7

Used this in 100nM for 24 hours in cultured cells and inhibited HIF1 level in the cells (checked by western blotting)

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