FM19G11

Product Description

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC₅₀ = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O⁶-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Solubility

Preparing Stock Solutions for FM19G11

The following data is based on the product molecular weight 463.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Alastrue-Agudo FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 2018 PMID: 29315225
• You FM19G11 inhibits O⁶-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 PMID: 29761922
• Moreno-Manzano FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 2010 PMID: 19897487