Fluoxetine hydrochloride

Name: Fluoxetine hydrochloride
Brand: Tocris Bioscience
SKU: 0927
Rating: 5 (1 reviews)

Catalog # 0927

Citations (10)

(1)

COA / SDS

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Key Product Details

Description:	5-HT reuptake inhibitor
Chemical Name:	N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	345.78

View Full Technical Details for Fluoxetine hydrochloride

Biological Activity

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K_i of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT_1A, 5-HT_2A, H₁, α₁, α₂-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries

Fluoxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	345.78
Formula	C₁₇H₁₈F₃NO.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	56296-78-7
PubChem ID	62857
InChi Key	GIYXAJPCNFJEHY-UHFFFAOYSA-N
Smiles	Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.58	100
	water	3.46	10

Preparing Stock Solutions

The following data is based on the product molecular weight 345.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.46 mL	28.92 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.45 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References

References are publications that support the biological activity of the product.

Ambati Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration. Proc.Natl.Acad.Sci.USA 2021 PMID: 34620711
Chang Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 2010 PMID: 19598107
Beck Fluoxetine selectively alters 5-hydroxytryptamine_1A and γ-aminobutyric acid_B receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 1997 PMID: 9103487
Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
Benfield Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 1986 PMID: 2878798

Citations for Fluoxetine hydrochloride (10)

Showing 1 - 10 of 10 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Fluoxetine hydrochloride include:

Kant et al. (2018) Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis. Front Immunol. 9:2508
PMID: 30429853
Zhang and Gaudry (2016) Functional integration of a serotonergic neuron in the Drosophila antennal lobe. Elife. 5
PMID: 27572257
Hooper et al. (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol. 311:H572
PMID: 27371685
Sallin and Jazwinska (2016) Acute stress is detrimental to heart regeneration in zebrafish. Open Biol. 6
PMID: 27030176
Pai et al. (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci. 35:4366
PMID: 25762681
Silva et al. (2014) Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS One. 9:e89641
PMID: 24586928
Stuart et al. (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology. 38:1625
PMID: 23503126
Kurita et al. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 15:1245
PMID: 22864611
Nozawa et al. (2009) TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 106:3408
PMID: 19211797
MacLean et al. (2004) Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. J Pharmacol Exp Ther. 109:2150
PMID: 15078799

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Fluoxetine decreases cued fear recall in c57bl6J mice

Name: Olivia Hon

Species: Mouse

Assay Type: In Vivo

10mg/kg fluoxetine hcl injected i.p. in male c57Bl6J mice before cued fear conditioning, significantly decreased freezing during fear recall 24 hours later

given 60 min before behavior, dissolved in.9% sterile saline

There are no reviews that match your criteria.