HG-9-91-01
Tocris Bioscience, part of Bio-Techne | Catalog # 8985
Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.
Key Product Details
Description
Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.
Alternative Names
SIK inhibitor 1
Product Description
HG-9-91-01 (SIK1 inhibitor) is a potent pan-salt inducible kinases (pan-SIKs) inhibitor (IC50 values are 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3 respectively). HG-9-91-01 inhibits latrunculin B (Lat-B)-induced endocrine progenitors (EP) differentiation via nuclear YAP1 accumulation in vitro. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in vitro. HG-9-91-01 increases β-cell proliferation in vitro and in vivo (mouse, zebrafish).Product Specifications
Molecular Weight
567.68
Formula
C32H37N7O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
CAS Number
1456858-58-4
PubChem ID
78357808
InChI Key
UYUHRKLITDJEHB-UHFFFAOYSA-N
SMILES
O=C(N(C1=CC=C(C=C1OC)OC)C2=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=N2)NC5=C(C)C=CC=C5C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.77 | 100 | |
| Ethanol | 5.68 | 10 |
Preparing Stock Solutions
for HG-9-91-01
The following data is based on the product molecular weight 567.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.76 mL | 8.81 mL | 17.62 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tian Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage. Stem Cell Rep. 2025 PMID: 40054471
- Charbord In vivo screen identifies a SIK inhibitor that induces beta cell proliferation through a transient UPR. Nat.Metab. 2021 PMID: 34031592
- Clark Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 23033494
Product Specific Notices for HG-9-91-01
For research use only
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