NVP-TNKS656
Tocris Bioscience, part of Bio-Techne | Catalog # 8913
Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
Key Product Details
Description
Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
Product Description
NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC50 values are 7.8 and 8.2 for TNKS1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.Product Specifications
Molecular Weight
494.58
Formula
C27H34N4O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide
CAS Number
1419949-20-4
PubChem ID
136237316
InChI Key
DYGBNAYFDZEYBA-UHFFFAOYSA-N
SMILES
O=C1N=C(NC2=C1COCC2)CN(C(=O)CN3CCC(C(=O)C4=CC=C(OC)C=C4)CC3)CC5CC5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.95 | 10 |
Preparing Stock Solutions
for NVP-TNKS656
The following data is based on the product molecular weight 494.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.22 mL | 101.10 mL | 202.19 mL |
| 0.5 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 1 mM | 2.02 mL | 10.11 mL | 20.22 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shultz Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J.Med.Chem. 2013 PMID: 23844574
- Medina-Cano A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro. Dev.Cell 2025 PMID: 40876454
Product Specific Notices for NVP-TNKS656
For research use only
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