CKI 7 dihydrochloride

Name: CKI 7 dihydrochloride
Brand: Tocris Bioscience
SKU: 5329

Tocris Bioscience, part of Bio-Techne | Catalog # 5329

Citations (3)

COA / SDS

CK1 inhibitor

Key Product Details

Description:	CK1 inhibitor
Chemical Name:	N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	358.67

View Full Technical Details for CKI 7 dihydrochloride

Technical Data
Citations

Biological Activity for CKI 7 dihydrochloride

CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

Compound Libraries for CKI 7 dihydrochloride

CKI 7 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CKI 7 dihydrochloride

M. Wt	358.67
Formula	C₁₁H₁₂ClN₃O₂S.2HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1177141-67-1
PubChem ID	16078955
InChi Key	JUAVTXYOCISSSL-UHFFFAOYSA-N
Smiles	ClC2=CC=C(S(NCCN)(=O)=O)C1=CN=CC=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CKI 7 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.59	10
	DMSO	17.93	50

Preparing Stock Solutions for CKI 7 dihydrochloride

The following data is based on the product molecular weight 358.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.58 mL	27.88 mL	55.76 mL
2.5 mM	1.12 mL	5.58 mL	11.15 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

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References for CKI 7 dihydrochloride

References are publications that support the biological activity of the product.

Rena D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 PMID: 14710188
Peifer 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 2009 PMID: 19591487
Osakada In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 2009 PMID: 19671662