Sodium butyrate

Name: Sodium butyrate
Brand: Tocris Bioscience
SKU: 3850

Tocris Bioscience a Bio-Techne Brand

Catalog # 3850

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Key Product Details

Description:	Histone deacetylase inhibitor
Chemical Name:	Butanoic acid sodium salt
Molecular Weight:	110.09

View Full Technical Details for Sodium butyrate

Biological Activity for Sodium butyrate

Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.

Technical Data for Sodium butyrate

M. Wt	110.09
Formula	C₄H₇NaO₂
Storage	Store at RT
CAS Number	156-54-7
PubChem ID	5222465
InChi Key	MFBOGIVSZKQAPD-UHFFFAOYSA-M
Smiles	[Na+].CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sodium butyrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.01	100

Preparing Stock Solutions for Sodium butyrate

The following data is based on the product molecular weight 110.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.08 mL	45.42 mL	90.83 mL
5 mM	1.82 mL	9.08 mL	18.17 mL
10 mM	0.91 mL	4.54 mL	9.08 mL
50 mM	0.18 mL	0.91 mL	1.82 mL

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References for Sodium butyrate

References are publications that support the biological activity of the product.

Yu Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J.Cell.Mol.Med. 2022 PMID: 35429101
Kilgore Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010 PMID: 20010553
Ren Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 2010 PMID: 19911386
Zhou Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 2010 PMID: 20039312
Liang Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 2010 PMID: 20554530
Ferrante Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J.Neurosci. 2003 PMID: 14561870
Boffa Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 1978 PMID: 649576

Citations for Sodium butyrate

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