Sodium butyrate

Product Description

Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.

Solubility

Preparing Stock Solutions for Sodium butyrate

The following data is based on the product molecular weight 110.09

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.08 mL	45.42 mL	90.83 mL
5 mM	1.82 mL	9.08 mL	18.17 mL
10 mM	0.91 mL	4.54 mL	9.08 mL
50 mM	0.18 mL	0.91 mL	1.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ferrante Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J.Neurosci. 2003 PMID: 14561870
• Yu Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J.Cell.Mol.Med. 2022 PMID: 35429101
• Liang Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 2010 PMID: 20554530
• Zhou Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 2010 PMID: 20039312
• Ren Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 2010 PMID: 19911386
• Kilgore Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010 PMID: 20010553
• Boffa Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 1978 PMID: 649576