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SP 600125

Catalog # 1496 | Tocris Bioscience a Bio-Techne Brand
Selective JNK inhibitor
Selective JNK inhibitor
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Key Product Details

Description: Selective JNK inhibitor
Chemical Name: Anthra[1-9-cd]pyrazol-6(2H)-one
Purity: ≥98% (HPLC)
Molecular Weight: 220.23

Citations for SP 600125 (108)

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  • Role of JNK activation in chemotherapy-induced apoptosis
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Human cancer cells were pretreated for 2 hours with SP600125 before addition of chemotherapeutics and were incubated for 72 hours. SP600125 was used at 1, 3 and 10 μM. Real time apoptosis assays were performed. JNK inhibition partially reversed the chemotherapeutics-induced cellular apoptosis.
  • JNK inhibition in LPA induced pro-inflammatory phenotype in microglia.
    Name: lisha joshi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    Primary murine microglia were treated with LPA (1µM) in the presence or absence of SP600125 (10µM) in order to investigate the role of JNK pathway in the LPA induced inflammatory phenotype. The inhibitor was well tolerated by the cells. DMSO was used as a vehicle control. Cells were lysed and collected for WB analysis in order to identify changes in the expression of COX2 and Arg1.
    SP 600125 Serum 1496
  • SP 600125 inhibits JNK activation in HOCl-LDL treated cardiomyocytes
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    HL-1 cardiomyocytes were treated with SP 600125 (5 or 10 μM, 30 min) followed by 500 μg/ml HOCl-LDL (oxidant:lipoprotein molar ratio=800:1) for 1 h to follow pJNK expression using Western blot. SP 600125 at 10 μM concentration, completely inhibited activation of JNK.
    SP 600125 Serum 1496
  • JNK inhibition in BV2 microglia
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia
    The inhibitor was used at a concentration of 10µM in BV2 microglia cell line. SP600125 inhibited the LPA induced activation of transcription factors (western blotting). It was also used in flow cytometry, ELISAs, IF and functional assays. The results were constant and reproducible.
    SP 600125 Serum 1496

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Product Documents for SP 600125

Certificate of Analysis

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