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Serpin E1/PAI-1 Products

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.

134 results for "Serpin E1/PAI-1" in Products

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Serpin E1/PAI-1 Products

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.

134 results for "Serpin E1/PAI-1" in Products

Simple Plex Human Serpin E1/PAI-1 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD06, and wash buffer.

ELISA, ICC/IF, IHC, WB
Catalog #: 898223
Ctrl

Control for use with Human Serpin E1/PAI-1 Simple Plex Cartridge Kit

Catalog #: QC157
ELISA, Ctrl

For use with catalog number DSE100

ICC/IF, IHC
CyTOF-ready, ELISA, Flow, IHC, WB
ELISA, ICC/IF, WB
ELISA, IHC, WB
Flow, ICC/IF, IP, WB

Recombinant Monoclonal Antibody

Catalog #: NBP1-19773PEP
AC
ELISA
ELISA
ELISA
ELISA
ELISA
ELISA
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