Serpin E1/PAI-1: Proteome Profiler Antibody Arrays
Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.
12 results for "Serpin E1/PAI-1 Proteome Profiler Antibody Arrays" in Products
12 results for "Serpin E1/PAI-1 Proteome Profiler Antibody Arrays" in Products
Serpin E1/PAI-1: Proteome Profiler Antibody Arrays
Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes - each spotted in duplicate with 38 different obesity-related antibodies
Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
Contains 4 membranes - each spotted in duplicate with 53 different angiogenesis antibodies
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
Contains 4 membranes - each spotted in duplicate with 32 different protease inhibitor antibodies
Contains 4 membranes - each spotted in duplicate with 30 different obesity-related antibodies