PI 3-Kinase Inhibitors Small Molecules and Peptides

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Potent pan-class I PI3 kinase inhibitor

Inhibitor of PI 3-kinase, mTOR and DNA-PK

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

Non-selective PI 3-kinase inhibitor

Potent and selective PI 3-kinase p110α inhibitor

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Class III PI 3-kinase inhibitor; also inhibits autophagy

Potent and selective PI 3-Kβ inhibitor

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

Potent PI 3-Kinase δ isoform inhibitor

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation