Omipalisib
Tocris Bioscience, part of Bio-Techne | Catalog # 6792
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
Key Product Details
Description
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
Alternative Names
GSK2126458
Product Description
Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.Product Specifications
Molecular Weight
505.50
Formula
C25H17F2N5O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
CAS Number
1086062-66-9
PubChem ID
25167777
InChI Key
CGBJSGAELGCMKE-UHFFFAOYSA-N
SMILES
COC1=NC=C(C2=CC3=C(N=CC=C3C4=CN=NC=C4)C=C2)C=C1NS(=O)(C5=C(C=C(C=C5)F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.11 | 20 |
Preparing Stock Solutions
for Omipalisib
The following data is based on the product molecular weight 505.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.89 mL | 49.46 mL | 98.91 mL |
| 1 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 2 mM | 0.99 mL | 4.95 mL | 9.89 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Knight Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 2010 PMID: 24900173
Product Specific Notices for Omipalisib
For research use only
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