Urolithin A

Name: Urolithin A
Brand: Tocris Bioscience
SKU: 6762

Tocris Bioscience a Bio-Techne Brand

Catalog # 6762

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Key Product Details

Description:	PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Chemical Name:	3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	228.2

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Biological Activity for Urolithin A

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC₅₀ values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Technical Data for Urolithin A

M. Wt	228.2
Formula	C₁₃H₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1143-70-0
PubChem ID	5488186
InChi Key	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Smiles	OC1=CC=C2C(OC(C3=CC(O)=CC=C23)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Urolithin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.82	100

Preparing Stock Solutions for Urolithin A

The following data is based on the product molecular weight 228.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.38 mL	21.91 mL	43.82 mL
5 mM	0.88 mL	4.38 mL	8.76 mL
10 mM	0.44 mL	2.19 mL	4.38 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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References for Urolithin A

References are publications that support the biological activity of the product.

Totiger Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 2019 PMID: 30404927
Yuan Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 2016 PMID: 26559394

Citations for Urolithin A

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