A66
Tocris Bioscience, part of Bio-Techne | Catalog # 5595
Potent and selective PI 3-kinase p110α inhibitor
Key Product Details
Description
Potent and selective PI 3-kinase p110α inhibitor
Product Description
A66 is a potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.Product Specifications
Molecular Weight
393.53
Formula
C17H23N5O2S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
CAS Number
1166227-08-2
PubChem ID
42636535
InChI Key
HBPXWEPKNBHKAX-NSHDSACASA-N
SMILES
CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.35 | 100 |
Preparing Stock Solutions
for A66
The following data is based on the product molecular weight 393.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jamieson A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 2011 PMID: 21668414
Product Specific Notices for A66
For research use only
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