A66

Name: A66
Brand: Tocris Bioscience
SKU: 5595

Tocris Bioscience a Bio-Techne Brand

Catalog # 5595

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Qty

Key Product Details

Description:	Potent and selective PI 3-kinase p110α inhibitor
Chemical Name:	(2S)-N¹-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	393.53

View Full Technical Details for A66

Biological Activity for A66

A66 is a potent and selective PI 3-kinase p110α inhibitor (IC₅₀ = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

Compound Libraries for A66

A66 is also offered as part of the Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for A66

M. Wt	393.53
Formula	C₁₇H₂₃N₅O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1166227-08-2
PubChem ID	42636535
InChi Key	HBPXWEPKNBHKAX-NSHDSACASA-N
Smiles	CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A66

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.35	100

Preparing Stock Solutions for A66

The following data is based on the product molecular weight 393.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.71 mL	25.41 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for A66

References are publications that support the biological activity of the product.

Jamieson A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 2011 PMID: 21668414

Citations for A66

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A66