PI 828
Tocris Bioscience, part of Bio-Techne | Catalog # 2814
PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
Key Product Details
Description
PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
Product Description
PI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.Product Specifications
Molecular Weight
322.36
Formula
C19H18N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
CAS Number
942289-87-4
PubChem ID
25181195
InChI Key
WUKMIBOGGXMBAC-UHFFFAOYSA-N
SMILES
O=C2C=C(N3CCOCC3)OC1=C(C4=CC=C(N)C=C4)C=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.24 | 100 |
Preparing Stock Solutions
for PI 828
The following data is based on the product molecular weight 322.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.20 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gharbi Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J. 2007 PMID: 17302559
Product Specific Notices for PI 828
For research use only
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