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PDGF R beta Products

PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.

54 results for "PDGF R beta" in Products

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PDGF R beta Products

PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.

54 results for "PDGF R beta" in Products

BA
BA
BA

Biotinylated

ELISA
BA
BA
BA
ELISA
ELISA
Catalog #: FAB1263R
Flow
Catalog #: FAB1263V
Flow
Catalog #: FAB1263G
Flow
Catalog #: FAB1263S
Flow
Catalog #: RDC1232
Catalog #: FAB1263T
Flow
Catalog #: FAB1263U
Flow
Catalog #: RDC0396
WB, Flow, IHC, CyTOF-ready, Neut
WB, Flow, IHC, IP
WB, Simple Western, ICC

Recombinant Monoclonal Antibody.

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