
PDGF R beta: Proteins and Enzymes
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
6 results for "PDGF R beta Proteins and Enzymes" in Products
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PDGF R beta: Proteins and Enzymes
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
6 results for "PDGF R beta Proteins and Enzymes" in Products
Source : | NS0 |
Accession # : | P09619 |
Applications : | Bioactivity |
Biotinylated
Source : | CHO |
Accession # : | AAA36427.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | Q05030.2 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | AAA36427.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | P05622 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | P05622 |
Applications : | Bioactivity |