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Cyclooxygenase Inhibitors: Small Molecules and Peptides
Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.
16 results for "Cyclooxygenase Inhibitors Small Molecules and Peptides" in Products
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Cyclooxygenase Inhibitors: Small Molecules and Peptides
Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.
16 results for "Cyclooxygenase Inhibitors Small Molecules and Peptides" in Products
Cyclooxygenase inhibitor; may be selective for COX-3
| Alternate Names : | Paracetamol |
| Chemical Name : | N-(4-Hydroxyphenyl)acetamide |
| Purity : | ≥99% (HPLC) |
Catalog #:
4454
Cyclooxygenase inhibitor; NSAID
| Chemical Name : | 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase inhibitor
| Chemical Name : | 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol |
| Purity : | ≥98% (HPLC) |
Selective cyclooxygenase-2 (COX-2) inhibitor
| Alternate Names : | SC 58635, Celebrex |
| Chemical Name : | 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide |
| Purity : | ≥99% (HPLC) |
Catalog #:
2796
Cyclooxygenase inhibitor (COX-1 > COX-2)
| Chemical Name : | (S)-α-Methyl-4-(2-methylpropyl)benzeneacetic acid |
| Purity : | ≥99% (HPLC) |
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
| Chemical Name : | 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase inhibitor; NSAID
| Chemical Name : | 2-Acetoxybenzoic acid |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase-2 (COX-2) inhibitor
| Chemical Name : | N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase-2 (COX-2) inhibitor
| Chemical Name : | 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene |
| Purity : | ≥99% (HPLC) |
Catalog #:
3919
Selective cyclooxygenase-2 (COX-2) inhibitor
| Alternate Names : | SC 58236 |
| Chemical Name : | 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide |
| Purity : | ≥99% (HPLC) |
Catalog #:
2580
NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3
| Alternate Names : | CP 66248 |
| Chemical Name : | (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase (COX-1) inhibitor
| Chemical Name : | 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride |
| Purity : | ≥98% (HPLC) |
Catalog #:
4206
Selective and potent COX-2 inhibitor
| Chemical Name : | 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase-1 (COX-1) inhibitor
| Chemical Name : | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
| Purity : | ≥98% (HPLC) |
Cyclooxygenase inhibitor (COX-1 > COX-2)
| Chemical Name : | 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole |
| Purity : | ≥99% (HPLC) |
Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
| Chemical Name : | 2-[3-(Trifluoromethyl)anilino]nicotinic acid |
