Acetaminophen

Name: Acetaminophen
Brand: Tocris Bioscience
SKU: 1706

Catalog # 1706 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Cyclooxygenase inhibitor; may be selective for COX-3

Key Product Details

Description:	Cyclooxygenase inhibitor; may be selective for COX-3
Alternative Names:	Paracetamol
Chemical Name:	N-(4-Hydroxyphenyl)acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	151.16

View Full Technical Details for Acetaminophen

Technical Data
Citations (3) / Reviews

Biological Activity for Acetaminophen

Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC₅₀ values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.

Compound Libraries for Acetaminophen

Acetaminophen is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Acetaminophen

M. Wt	151.16
Formula	C₈H₉NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	103-90-2
PubChem ID	1983
InChi Key	RZVAJINKPMORJF-UHFFFAOYSA-N
Smiles	CC(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Acetaminophen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	15.12	100
	DMSO	15.12	100

Preparing Stock Solutions for Acetaminophen

The following data is based on the product molecular weight 151.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.62 mL	33.08 mL	66.16 mL
5 mM	1.32 mL	6.62 mL	13.23 mL
10 mM	0.66 mL	3.31 mL	6.62 mL
50 mM	0.13 mL	0.66 mL	1.32 mL

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Reconstitution Calculator

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References for Acetaminophen

References are publications that support the biological activity of the product.

Chandrasekharan COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12242329
Chong Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 2001 PMID: 11724102
Riendeau Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 1997 PMID: 9365818

Citations for Acetaminophen (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Acetaminophen include:

Inagaki et al. (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci. 13:13
PMID: 23137391
Factor et al. (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 104:4083
PMID: 17360481
Liu and Gao (2007) Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol. 97:837
PMID: 17093123

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