Resveratrol

Name: Resveratrol
Brand: Tocris Bioscience
SKU: 1418

Tocris Bioscience a Bio-Techne Brand

Catalog # 1418

Citations (7)

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Key Product Details

Description:	Cyclooxygenase inhibitor
Chemical Name:	5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
Purity:	≥98% (HPLC)
Molecular Weight:	228.25

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Biological Activity for Resveratrol

Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC₅₀ = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1. Activates autophagy. Also activates TRPA1 in prostate cancer-associated fibroblasts. Also SIRT1 activator.

Compound Libraries for Resveratrol

Resveratrol is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Resveratrol

M. Wt	228.25
Formula	C₁₄H₁₂O₃
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	501-36-0
PubChem ID	445154
InChi Key	LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Smiles	OC1=CC=C(C=C1)\C=C\C1=CC(O)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Resveratrol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol		100
	DMSO	22.82	100

Preparing Stock Solutions for Resveratrol

The following data is based on the product molecular weight 228.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.38 mL	21.91 mL	43.81 mL
5 mM	0.88 mL	4.38 mL	8.76 mL
10 mM	0.44 mL	2.19 mL	4.38 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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References for Resveratrol

References are publications that support the biological activity of the product.

Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Vancauwenberghe Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Mol.Carcinog. 2017 PMID: 28277613
Baptista Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer. Oncotarget 2013 PMID: 24127549
Baur and Sinclair Therapeutic potential of resveratrol: the in vivo evidence. Nat.Rev.Drug Discov. 2006 PMID: 16732220
Bowers Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology 2000 PMID: 11014220
Fremont Biological effects of resveratrol. Life Sci. 2000 PMID: 10680575
Chun Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem.Biophys.Res.Commun. 1999 PMID: 10448061
Kimura Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim.Biophys.Acta 1985 PMID: 3922423

Citations for Resveratrol (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Resveratrol include:

Meftahi et al. (2015) Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons. Evid Based Complement Alternat Med. 17:532
PMID: 26464825
Chen et al. (2014) A critical role for IF. regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 34:11897
PMID: 25186738
Rojas et al. (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci. 8:24
PMID: 24570655
Jiang and Zsombok (2014) Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci. 7:270
PMID: 24454277
Wang et al. (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Cancer Res. 2013:857929
PMID: 23762164
Pacholec et al. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem. 285:8340
PMID: 20061378
Ohshiro et al. (2007) Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Br J Pharmacol. 67:8164
PMID: 17804729

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