Valdecoxib

Name: Valdecoxib
Brand: Tocris Bioscience
SKU: 4206

Tocris Bioscience, part of Bio-Techne | Catalog # 4206

Citations (1)

COA / SDS

Selective and potent COX-2 inhibitor

Key Product Details

Description:	Selective and potent COX-2 inhibitor
Chemical Name:	4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	314.36

View Full Technical Details for Valdecoxib

Technical Data
Citations

Biological Activity for Valdecoxib

Valdecoxib is a selective and potent COX-2 inhibitor (in vitro IC₅₀ values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Valdecoxib

Valdecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Valdecoxib

M. Wt	314.36
Formula	C₁₆H₁₄N₂O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	181695-72-7
PubChem ID	119607
InChi Key	LNPDTQAFDNKSHK-UHFFFAOYSA-N
Smiles	CC1=C(C3=CC=C(S(=O)(N)=O)C=C3)C(C2=CC=CC=C2)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valdecoxib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.44	100

Preparing Stock Solutions for Valdecoxib

The following data is based on the product molecular weight 314.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Valdecoxib

References are publications that support the biological activity of the product.

Walker A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 2001 PMID: 11463341
Gierse Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 2005 PMID: 15494548
Talley 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 2000 PMID: 10715145