Valdecoxib

Name: Valdecoxib
Brand: Tocris Bioscience
SKU: 4206

Tocris Bioscience a Bio-Techne Brand

Catalog # 4206

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Selective and potent COX-2 inhibitor
Chemical Name:	4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	314.36

View Full Technical Details for Valdecoxib

Biological Activity for Valdecoxib

Valdecoxib is a selective and potent COX-2 inhibitor (in vitro IC₅₀ values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Valdecoxib

Valdecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Valdecoxib

M. Wt	314.36
Formula	C₁₆H₁₄N₂O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	181695-72-7
PubChem ID	119607
InChi Key	LNPDTQAFDNKSHK-UHFFFAOYSA-N
Smiles	CC1=C(C3=CC=C(S(=O)(N)=O)C=C3)C(C2=CC=CC=C2)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valdecoxib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.44	100

Preparing Stock Solutions for Valdecoxib

The following data is based on the product molecular weight 314.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Valdecoxib

References are publications that support the biological activity of the product.

Gierse Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 2005 PMID: 15494548
Walker A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 2001 PMID: 11463341
Talley 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 2000 PMID: 10715145

Citations for Valdecoxib

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.