Diclofenac sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 4454
Cyclooxygenase inhibitor; NSAID
Key Product Details
Description
Cyclooxygenase inhibitor; NSAID
Product Description
Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).Product Specifications
Molecular Weight
318.13
Formula
C14H10Cl2NNaO2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
CAS Number
15307-79-6
PubChem ID
5018304
InChI Key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
SMILES
[Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.91 | 50 | |
| DMSO | 31.81 | 100 |
Preparing Stock Solutions
for Diclofenac sodium salt
The following data is based on the product molecular weight 318.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.72 mL | 31.43 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bort Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 1998 PMID: 9862754
- Laneuville Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 1994 PMID: 7965814
- Warner Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 1999 PMID: 10377455
Product Specific Notices for Diclofenac sodium salt
For research use only
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