Indomethacin

Name: Indomethacin
Brand: tocris
SKU: 1708

Catalog # 1708

Citations (6)

Datasheet / COA / SDS

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Key Product Details

Description:	Cyclooxygenase inhibitor (COX-1 > COX-2)
Chemical Name:	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Purity:	≥99% (HPLC)
Molecular Weight:	357.79

View Full Technical Details for Indomethacin

Biological Activity

Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC₅₀ values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

Technical Data

M. Wt	357.79
Formula	C₁₉H₁₆ClNO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	53-86-1
PubChem ID	3715
InChi Key	CGIGDMFJXJATDK-UHFFFAOYSA-N
Smiles	COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	17.89	50 with gentle warming
	DMSO	35.78	100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References

References are publications that support the biological activity of the product.

Palomer Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 2002 PMID: 11906281
Shen and Winter Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 1977 PMID: 343530
Walters and Willoughby Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 1965 PMID: 5849618
Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859

Citations (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Indomethacin include:

Gonnermann et al. (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology. 4:e988460
PMID: 25949900
Cramer et al. (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Biomed Sci. 35:5664
PMID: 25855180
Allen et al. (2015) DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol. 5:260
PMID: 26697402
Tang et al. (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun. 5:3284
PMID: 24518663
Flamm et al. (2012) Multiscale prediction of patient-specific platelet function under flow. Blood. 120:190
PMID: 22517902
Miller et al. (2012) CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 109:20602
PMID: 23185004

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Showing 1 - 6 of 6 citations Showing All

Product Documents

COA

Certificate of Analysis

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Indomethacin

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References

Citations (6)

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COA

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